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To address these challenges, we developed allogeneic IL-15\u2013enhanced, mesothelin-specific CAR-engineered invariant natural killer T (\n                    <jats:sup>Allo15<\/jats:sup>\n                    MCAR-NKT) cells through gene engineering of human hematopoietic stem and progenitor cells (HSPCs) using a clinically guided culture method. These\n                    <jats:sup>Allo15<\/jats:sup>\n                    MCAR-NKT cells exhibited robust and multifaceted antitumor activity against PC, driven by both CAR and NK receptor\u2013mediated cytotoxic mechanisms. In orthotopic and metastatic human PC xenograft models,\n                    <jats:sup>Allo15<\/jats:sup>\n                    MCAR-NKT cells demonstrated superior tumor control, enhanced trafficking and infiltration into tumor sites, sustained effector and cytotoxic phenotypes, and reduced expression of exhaustion markers. 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