{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:37:16Z","timestamp":1793356636478,"version":"4.5.0"},"reference-count":91,"publisher":"National Academy of Sciences","issue":"52","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1K23NS136767"],"award-info":[{"award-number":["1K23NS136767"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"HHS | NIH | National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["U01EB034228"],"award-info":[{"award-number":["U01EB034228"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["CDA"],"award-info":[{"award-number":["CDA"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS128961"],"award-info":[{"award-number":["R01NS128961"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS138258"],"award-info":[{"award-number":["R01NS138258"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH113929"],"award-info":[{"award-number":["R01MH113929"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,12,30]]},"abstract":"<jats:p>\n                    Some patients with moderate to severe traumatic brain injury (TBI) make a full recovery, while others remain severely disabled. Accurate prognostication is important, because withdrawal of life-sustaining therapy based on perceived poor prognosis is the leading cause of death after TBI. Synchronized activity between brain regions, measurable with resting-state functional MRI (rs-fMRI), may underlie neurological recovery. However, which functional connections are critical for recovery, and whether functional connectivity measured shortly after brain injury predicts long-term recovery, is unknown. Here, we analyzed data from three prospective cohorts of patients with moderate or severe TBI (N = 116 patients; 134 controls) who underwent rs-fMRI shortly after injury. The strongest predictor of 6-mo functional outcomes in the Training Cohort (mean cross validation AUC 0.94) and independent Testing Cohort (AUC 0.78;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.001) was functional connectivity between three pairs of brain regions from functionally distinct networks, two of which were anticorrelated. Results were robust to controlling for sedation (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.02) and level of consciousness at time of MRI (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.02). Finally, preserved anticorrelations improved the leave-one-out outcome prediction accuracy of an established prognostic score (AUC 0.90 vs. 0.80;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.02). Preserved functional anticorrelations in acutely traumatized brains identify patients with the neurological substrate required for recovery. This biomarker can inform prognostic decisions in patients at high risk for death from withdrawal of life-sustaining therapy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2518159122","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T20:00:56Z","timestamp":1766433656000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":5,"title":["Preservation of anticorrelated brain networks predicts recovery after traumatic brain injury"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-7890","authenticated-orcid":false,"given":"Samuel B.","family":"Snider","sequence":"first","affiliation":[{"name":"Division of Neurocritical Care, Department of Neurology, Brigham and Women\u2019s Hospital","place":["Boston"]},{"name":"Harvard Medical School","place":["Boston"]},{"name":"Center for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry and Radiology, Brigham and Women\u2019s Hospital","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1096-5836","authenticated-orcid":false,"given":"Hui","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Neurocritical Care, Department of Neurology, Brigham and Women\u2019s Hospital","place":["Boston"]},{"name":"Center for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry and Radiology, Brigham and Women\u2019s Hospital","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena G.","family":"Bodien","sequence":"additional","affiliation":[{"name":"Department Surgery, Vanderbilt University Medical Center","place":["Nashville"]},{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center","place":["Nashville"]},{"name":"Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Howard","sequence":"additional","affiliation":[{"name":"Center for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry and Radiology, Brigham and Women\u2019s Hospital","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Sun","sequence":"additional","affiliation":[{"name":"Biostatistics Research Center, Herbert Wertheim School of Public Health, University of California San Diego","place":["San Diego"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J.","family":"Golby","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston"]},{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-3414","authenticated-orcid":false,"given":"Karl A.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"United Kingdom Dementia Research Institute, Care Research and Technology Centre, Imperial College London","place":["London, United Kingdom"]},{"name":"Department of Brain Sciences, Hammersmith Hospital, Imperial College London","place":["London, United Kingdom"]},{"name":"Human Experience Analysis and Design (HEAD) Lab, Dyson School of Design Engineering, Imperial College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-4259","authenticated-orcid":false,"given":"Guido","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS","place":["Bergamo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1723-0844","authenticated-orcid":false,"given":"Sandra","family":"Magnoni","sequence":"additional","affiliation":[{"name":"Anesthesiology and Pain Medicine Service, Department of Medicine, Surgery and Pharmacy, University of Sassari","place":["Sassari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-4561","authenticated-orcid":false,"given":"Vincent","family":"Dunet","sequence":"additional","affiliation":[{"name":"Radiology Department, Lausanne University Hospital (CHUV)","place":["Lausanne, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6155-2525","authenticated-orcid":false,"given":"Mauro","family":"Oddo","sequence":"additional","affiliation":[{"name":"Clinical Research Center and Directorate of Innovation and Clinical Research, Lausanne University Hospital (CHUV), Faculty of Biology and Medicine, University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil S. N.","family":"Graham","sequence":"additional","affiliation":[{"name":"United Kingdom Dementia Research Institute, Care Research and Technology Centre, Imperial College London","place":["London, United Kingdom"]},{"name":"Department of Brain Sciences, Hammersmith Hospital, Imperial College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma-Jane","family":"Mallas","sequence":"additional","affiliation":[{"name":"United Kingdom Dementia Research Institute, Care Research and Technology Centre, Imperial College London","place":["London, United Kingdom"]},{"name":"Department of Brain Sciences, Hammersmith Hospital, Imperial College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-5583","authenticated-orcid":false,"given":"Federico","family":"Moro","sequence":"additional","affiliation":[{"name":"Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri Istituto di Ricovero e Cura a Carattere Scientifico","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7473-7409","authenticated-orcid":false,"given":"Pratik","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California San Francisco","place":["San Francisco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6392-5292","authenticated-orcid":false,"given":"Nancy R.","family":"Temkin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington","place":["Seattle"]},{"name":"Department of Biostatistics, University of Washington","place":["Seattle"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-1247","authenticated-orcid":false,"given":"Sonia","family":"Jain","sequence":"additional","affiliation":[{"name":"Biostatistics Research Center, Herbert Wertheim School of Public Health, University of California San Diego","place":["San Diego"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Sharp","sequence":"additional","affiliation":[{"name":"United Kingdom Dementia Research Institute, Care Research and Technology Centre, Imperial College London","place":["London, United Kingdom"]},{"name":"Department of Brain Sciences, Hammersmith Hospital, Imperial College London","place":["London, United Kingdom"]},{"name":"The Imperial Centre for Injury Studies, Imperial College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7235-8456","authenticated-orcid":false,"given":"Brian L.","family":"Edlow","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston"]},{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital","place":["Boston"]},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital","place":["Charlestown"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Fox","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston"]},{"name":"Center for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry and Radiology, Brigham and Women\u2019s Hospital","place":["Boston"]},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital","place":["Charlestown"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.2043"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05965-z"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00309-X"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050165"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2023.11.JNS231425"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39461.643438.25"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31824519ce"},{"key":"e_1_3_4_8_2","first-page":"19","article-title":"Clinical applications of resting state functional connectivity","volume":"4","author":"Fox M. D.","year":"2010","unstructured":"M. D. Fox, M. Greicius, Clinical applications of resting state functional connectivity. Front. Syst. Neurosci. 4, 19 (2010).","journal-title":"Front. Syst. Neurosci."},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194144"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01736-x"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4179"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01114-5"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113148109"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws041"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07805-2"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn0441"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.07.021"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2218958120"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz239"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.029"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.05.004"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.03.012"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004406"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.03.017"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.38"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11941-6"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-023-01816-z"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-042093"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abg9922"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx176"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","unstructured":"Y. G. Bodien Multimodal biomarkers of consciousness in acute severe traumatic brain injury. J. Neurotrauma 10.1177\/08977151251377469 (2025).","DOI":"10.1177\/08977151251377469"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1998.15.573"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.8958"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507581"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002619"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207363"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_3_4_38_2","first-page":"58","article-title":"Symmetric atlasing and model based segmentation: An application to the hippocampus in older adults","volume":"9","author":"Grabner G.","year":"2006","unstructured":"G. Grabner , Symmetric atlasing and model based segmentation: An application to the hippocampus in older adults. Med. Image Comput. Comput. Assist. Interv. 9, 58\u201366 (2006).","journal-title":"Med. Image Comput. Comput. Assist. Interv."},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.06.078"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","unstructured":"A. Nieto-Castanon S. Whitfield-Gabrieli CONN functional connectivity toolbox: RRID SCR_009550 release 22 (2022). 10.56441\/hilbertpress.2246.5840.","DOI":"10.56441\/hilbertpress.2246.5840"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.002"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1109\/83.935035"},{"issue":"1","key":"e_1_3_4_43_2","first-page":"S287","article-title":"The diagnosis of head injury requires a classification based on computed axial tomography","volume":"9","author":"Marshall L. F.","year":"1992","unstructured":"L. F. Marshall , The diagnosis of head injury requires a classification based on computed axial tomography. J. Neurotrauma 9 (suppl. 1), S287\u2013S292 (1992).","journal-title":"J. Neurotrauma"},{"key":"e_1_3_4_44_2","unstructured":"E. W. Steyerberg IMPACT score for outcomes in head injury [online]. https:\/\/www.mdcalc.com\/calc\/10014\/impact-score-outcomes-head-injury. Accessed 6 May 2024."},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.02.033"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0199"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx179"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100012"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181f697f5"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1138-17.2019"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604187103"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.2\/smarek"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014030"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.008"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.03.021"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00244"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418031112"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217691110"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312848110"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat7603"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00111-3"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007645"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017162161"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25838"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12591-y"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3857"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104736"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109081"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt162"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr175"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0518-14.2014"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113455109"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06011.x"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2555"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0254-0"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003404"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3003"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.27772"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06583-z"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182755558"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.05.015"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.035"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.3671"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6153"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7499"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.026"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90426.2008"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.12.007"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2518159122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T20:01:38Z","timestamp":1766433698000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2518159122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":91,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2025,12,30]]}},"alternative-id":["10.1073\/pnas.2518159122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2518159122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2518159122"}}