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Notably, cb1 provided cross-protection not only against diverse SARS-CoV-2 variants of concern but also against more divergent SARS-CoV-1 and hCoV-OC43, a breadth of immunity unparalleled by current vaccines. These findings highlight the potential of cb1 to address urgent needs for next-generation COVID-19 vaccines that elicit mucosal immunity with broad, long-lasting efficacy, eliminating the necessity for frequent updates.<\/jats:p>","DOI":"10.1073\/pnas.2518645123","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:50:12Z","timestamp":1769194212000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Broad beta-CoV immunity and transmission blockade by a single-dose live-attenuated vaccine with atypical codon usage"],"prefix":"10.1073","volume":"123","author":[{"given":"Nigeer","family":"Te","sequence":"first","affiliation":[{"name":"School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Wing 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