{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:49:48Z","timestamp":1781110188550,"version":"3.54.1"},"reference-count":21,"publisher":"National Academy of Sciences","issue":"37","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,9,16]]},"abstract":"<jats:p>\n                    The 2025 Lasker~DeBakey Clinical Medical Research Award has been given to Michael Welsh, Jes\u00fas (Tito) Gonz\u00e1lez, and Paul Negulescu for their key roles in developing a novel treatment for cystic fibrosis (CF)\u2014a three-drug combination that saves the lives of people with this lethal genetic disease [D. Keating\n                    <jats:italic toggle=\"yes\">et al.<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">N. Engl. J. Med.<\/jats:italic>\n                    379, 1612\u20131620 (2018)]. The disease is caused by mutations that disrupt the function of a gene known as CF Transmembrane Conductance Regulator which encodes a chloride channel expressed in epithelial cells including the lung. Collectively the three recipients were responsible for the development of novel high-throughput drug screens that led to the development of the new drugs. Welsh is a pulmonologist who played a key role in understanding the physiology and pathophysiology of the disease. Gonz\u00e1lez is a physical organic chemist who developed a novel technology that enabled robust high-throughput screens for drugs that correct the channel defects. Negulescu led a group of extremely talented biologists, chemists, and physicians who built on these advances to develop novel three-drug combinations that have miraculous benefits for the majority of afflicted patients. This advance represents a true milestone in medicine and fulfills a dream of research scientists and families\u2014the conversion of a fatal disease into a fully treatable one. It is also a stunning example of the power of medical research to save people\u2019s lives.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2519780122","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:00:31Z","timestamp":1757595631000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Cystic fibrosis: Correction of a fatal disease"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2152-0868","authenticated-orcid":false,"given":"Jeffrey M.","family":"Friedman","sequence":"first","affiliation":[{"name":"HHMI at Rockefeller University","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_3_4_1_2","volume-title":"Breath from Salt: A Deadly Genetic Disease, a New Era in Science, and the Patients and Families Who Changed Medicine Forever","author":"Trivedi B. 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