{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:50:50Z","timestamp":1790297450680,"version":"4.1.0"},"reference-count":60,"publisher":"National Academy of Sciences","issue":"18","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31930061 21790394 31761133016 31821091 31330024 31171026 31327901"],"award-info":[{"award-number":["31930061 21790394 31761133016 31821091 31330024 31171026 31327901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:p>Norepinephrine (NE) in the peripheral nervous system plays crucial roles in regulating peripheral organs in health and disease. However, the spatiotemporal dynamics of sympathetic NE release and its underlying mechanisms remain poorly characterized due to technical challenges. Here, we developed and validated a Slice ElectroChemistry (SEC) method to record sympathetic NE release in heart slices with combined super-resolution and high sensitivity at 1 \u03bcm \u00d7 1 ms \u00d7 1 nM as in patch-clamp recordings. By using the SEC method, we revealed the increased NE release, impaired NE reuptake, increased releasable NE-vesicle pool, and impaired vesicle recycling of sympathetic nerves in the heart of transverse aortic constriction-induced heart failure (HF) mouse model, and defined the increased expression of Cav2.2 calcium channel as a central mechanism mediating the facilitation of NE release and thus the pathogenesis of HF, clarifying a longstanding puzzle about the kinetic changes of cardiac sympathetic NE release in HF. Beyond the heart, SEC enables NE release recording in other peripheral organs and human tissues, providing a robust toolset to investigate sympathetic NE dynamics across diverse pathophysiological conditions.<\/jats:p>","DOI":"10.1073\/pnas.2519828123","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:05:09Z","timestamp":1777316709000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Physiological super-resolution in situ recording reveals kinetic changes of sympathetic norepinephrine release in heart failure"],"prefix":"10.1073","volume":"123","author":[{"given":"Bing","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Chongqing Key Laboratory of Brain and Aerospace Intelligence and Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-4118","authenticated-orcid":false,"given":"Xiaohan","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Institute of Basic Medical Science, Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjiang","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Institute of Basic Medical Science, Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"School of Basic Medical Sciences, Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhong","family":"Ou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Department of Physiology, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-7076","authenticated-orcid":false,"given":"Tian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingli","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Institute of Basic Medical Science, Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7407-4932","authenticated-orcid":false,"given":"Yun","family":"Xiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Institute of Basic Medical Science, Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8647-1011","authenticated-orcid":false,"given":"Qian","family":"Lei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Fuwai Hospital and Institute of Basic Medical Science, Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huadong","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Fuwai Hospital and Institute of Basic Medical Science, Peking Union Medical College","place":["Beijing, China"]},{"name":"Department of Anesthesiology, Beijing AnZhen Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghong","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Capital Sport University, Capital University of Physical Education and Sports","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feipeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Institute of Genetics and Developmental Biology, Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-409X","authenticated-orcid":false,"given":"Ruiping","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, State Key Laboratory of Vascular Homeostasis and Remodeling, Institute of Advanced Clinical Medicine, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University","place":["Beijing, China"]},{"name":"Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5902-2277","authenticated-orcid":false,"given":"Changhe","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]},{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University","place":["Luzhou, China"]},{"name":"Neuroscience Research Center, National Key Laboratory for High Energy Pulsed Power, Key Laboratory of Biomedical Information Engineering of The Ministry of Education, School of Life Science and Technology, Xi\u2019an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihuan","family":"Li","sequence":"additional","affiliation":[{"name":"Fuwai Hospital and Institute of Basic Medical Science, Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-555X","authenticated-orcid":false,"given":"Jimin","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Science, Peking Union Medical College","place":["Beijing, China"]},{"name":"Key Laboratory of Cellular Physiology under Ministry of Education, Department of Physiology, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-6638","authenticated-orcid":false,"given":"Zhuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology and Peking-Tsinghua Center for Life Sciences and International Data Group\/McGovern Institute for Brain Research, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1902"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/415198a"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.055"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2527-y"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.01.012"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz9124"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2235-7"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay1497"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5072"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1935-3"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.031"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.4.615"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.1.136"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2011.08.007"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.015"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2019.02.009"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112164"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.3.1299"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114294"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00219-4"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902444116"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.037"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-01959-z"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.03.001"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09901-2"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-019-02836-6"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580998"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111199"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608897104"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1617"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/356060a0"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02593-y"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120027"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2388-4"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1506"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.15.6938"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408484111"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4925"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01519-w"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.4.1697"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.11.4220"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4AN02074J"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-05-01879.2003"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.132.3423.351.b"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/46040"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.022"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs041"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/RES.0b013e3182582523"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0380-8"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1583"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx227"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2447647"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.4.403"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00223.2013"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa018"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0188"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(93)90094-8"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07440.x"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.031"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2519828123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:05:46Z","timestamp":1777316746000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2519828123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":60,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,5,5]]}},"alternative-id":["10.1073\/pnas.2519828123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2519828123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"2025-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2519828123"}}