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Transcriptomic profiling revealed that Sox10-deficiency in Neu+ tumor cells induces a luminal-to-basal\/mesenchymal-like shift and the downregulation of several genes associated with genetic networks regulating stemness. Collectively, these findings demonstrate that Sox10 is required for a permissive luminal cell state for Neu-driven tumor initiation and that it is critical for cancer stem cell activity and the establishment of metastases.<\/jats:p>","DOI":"10.1073\/pnas.2520063123","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T17:35:51Z","timestamp":1787333751000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Loss of Sox10 prevents tumor initiation in vivo and induces luminal-to-basal reprogramming in Neu+ tumor cells"],"prefix":"10.1073","volume":"123","author":[{"given":"Brennan","family":"Garland","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03c4mmv16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cellular and Molecular Medicine, University of Ottawa","place":["Ottawa, 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