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During infection with\n                    <jats:italic toggle=\"yes\">\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    <\/jats:italic>\n                    Typhimurium, depletion of SAILR sensitizes macrophages to apoptosis, resulting in loss of intracellular replication niches and reduced bacterial recovery. Conversely, enforced SAILR expression promotes macrophage survival and increases intracellular pathogen burden. Mechanistically, SAILR interacts with the antiapoptotic adaptor protein 14-3-3\u03b2 to support macrophage survival. Notably, downregulation of SAILR is mirrored in circulating immune cells from patients with severe COVID-19 and sepsis. Together, our findings position SAILR as a central regulator in linking macrophage survival to host\u2013pathogen interaction and disease pathophysiology.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2520205123","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:59:54Z","timestamp":1784221194000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-0169","authenticated-orcid":false,"given":"Alexander J.","family":"Westermann","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, Biocenter, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]},{"id":[{"id":"https:\/\/ror.org\/03d0p2685","id-type":"ROR","asserted-by":"publisher"}],"name":"Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research","place":["W\u00fcrzburg, Germany"]},{"name":"Cluster for Nucleic Acid Sciences and Technologies","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-8104","authenticated-orcid":false,"given":"Alexandra","family":"Schock","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Infection Biology, Faculty of Medicine, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-0001","authenticated-orcid":false,"given":"Diyaa Al Din","family":"Ashour","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pvr2g57","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]},{"id":[{"id":"https:\/\/ror.org\/03pvr2g57","id-type":"ROR","asserted-by":"publisher"}],"name":"Comprehensive Heart Failure Center, Department of Internal Medicine I, University Hospital W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5218-7245","authenticated-orcid":false,"given":"Sarah","family":"Wende","sequence":"additional","affiliation":[{"name":"Institute for Lung Research, Faculty of Medicine, Philipps University Marburg","place":["Marburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5194-5635","authenticated-orcid":false,"given":"Chrysanthi","family":"Skevaki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/023b0x485","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Clinical Chemistry and Laboratory Medicine, and Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg-University Mainz","place":["Mainz, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05g1y0660","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Laboratory Medicine, Faculty of Medicine, Philipps University Marburg","place":["Marburg, Germany"]},{"id":[{"id":"https:\/\/ror.org\/045f0ws19","id-type":"ROR","asserted-by":"publisher"}],"name":"Universities of Giessen and Marburg Lung Center","place":["Giessen, Germany"]},{"name":"Department of Environmental Health, Harvard T.H. 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