{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:31:45Z","timestamp":1791322305559,"version":"4.3.1"},"reference-count":89,"publisher":"National Academy of Sciences","issue":"5","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172402"],"award-info":[{"award-number":["32172402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key projects of Natural Science Foundation of Zhejiang Province","award":["LZ26C140001"],"award-info":[{"award-number":["LZ26C140001"]}]},{"name":"HZNU scientific research and innovation team project","award":["TD2025005"],"award-info":[{"award-number":["TD2025005"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:p>\n                    Whiteflies pose a major threat to crops worldwide, primarily because they transmit begomoviruses with which they have evolved intricate mutualistic relationships. The mutualisms are known to exacerbate whitefly invasions and drive widespread plant virus pandemics. Yet, certain plant genotypes are able to resist both the whiteflies and the viruses and a good understanding of the underlying mechanisms could help to develop more resistant varieties. Here, we show that the viruliferous whitefly\n                    <jats:italic toggle=\"yes\">Bemisia tabaci<\/jats:italic>\n                    induces an early and strong release of the sesquiterpene \u03b2-caryophyllene in cultivated tomato plants. This volatile functions as an airborne signal that primes neighboring conspecifics for enhanced resistance to begomoviruses, including Tomato yellow leaf curl virus and Papaya leaf curl China virus. These results challenge the view that whitefly-induced volatile emissions primarily benefit the insect vector, suggesting instead that the plant prioritizes antiviral defense over antiherbivore resistance. \u03b2-Caryophyllene exposure was also found to enhance the emission of \u03b2-Caryophyllene, methyl salicylate and \u03b2-myrcene upon whitefly attack, increasing plant attractiveness to the parasitoid\n                    <jats:italic toggle=\"yes\">Encarsia formosa<\/jats:italic>\n                    . Using a \u03b2-caryophyllene overproducing transgenic tomato line and synthetic \u03b2-caryophyllene dispensers, we confirmed that \u03b2-caryophyllene exposure primes antipathogen defenses in tomato plants and confers improved plant fitness under sustained infestation by viruliferous whiteflies. Importantly, this defense priming is genotype-specific and limited to certain tomato cultivars, suggesting that \u03b2-caryophyllene-mediated resistance can be harnessed through selective breeding. Our findings reveal a volatile-based mechanism by which tomato plants may counteract the virus\u2013vector mutualism, offering promising avenues for integrated pest and disease management.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2520719123","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T20:01:11Z","timestamp":1769457671000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":4,"title":["Airborne \u03b2-caryophyllene disrupts virus\u2013vector mutualism by priming tomato defenses"],"prefix":"10.1073","volume":"123","author":[{"given":"Peng-Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Chen","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Research Institute of Leisure Agriculture, Jiangsu Academy of Agricultural Sciences","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jian","family":"Wan","sequence":"additional","affiliation":[{"name":"Institute of Vegetables, Zhejiang Academy of Agricultural Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-7615","authenticated-orcid":false,"given":"Da-Wei","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0094-5368","authenticated-orcid":false,"given":"Bao-Li","family":"Qiu","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Vector Insects, College of Life Sciences, Chongqing Normal University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-785X","authenticated-orcid":false,"given":"Ted C. J.","family":"Turlings","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University","place":["Hangzhou, China"]},{"name":"Laboratory of Plant-Insect Research for Sustainable Agriculture, State Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, School of Life Sciences, Henan University","place":["Kaifeng, China"]},{"name":"Laboratory of Fundamental and Applied Research in Chemical Ecology, Institute of Biology, University of Neuch\u00e2tel","place":["Neuch\u00e2tel, Switzerland"]},{"name":"Department of Entomology, The Pennsylvania State University","place":["University Park"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1360-1385(03)00007-4"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.022508.092135"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(06)67011-5"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.142661"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2012.05457.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ele.12055"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.133181"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/v8080225"},{"key":"e_1_3_4_9_2","first-page":"9","article-title":"A plant virus manipulates both its host plant and the insect that facilitates its transmission","volume":"11","author":"Liang P.","year":"2024","unstructured":"P. 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