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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:p>\n                    Thymic epithelial tumors (TETs), rare yet clinically significant malignancies, face diagnostic challenges due to their occult presentation and lack of noninvasive risk-stratification tools, leading to systemic overtreatment and poor prognoses for high-risk subtypes. To address this unmet need, we developed a Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Fe metal\u2013organic framework heterojunction-enhanced laser desorption ionization mass spectrometry (LDI MS) platform for the efficient analysis of serum metabolic fingerprints (SMFs). Engineered through gradient pyrolysis, this nanomaterial synergizes ultraviolet absorption and photothermal conversion from its two constituent components with enhanced charge separation, achieving 1,000-fold improvement in sensitivity and thus enabling direct SMF acquisition from 1 \u03bcL of serum. Coupled with machine learning, the platform demonstrates robust diagnostic performance, yielding area under the curve (AUC) of 0.960 for distinguishing TETs from benign control and AUC of 0.856 for hierarchical risk stratification, outperforming clinical workflows. Beyond advancing material design for LDI MS, this work establishes a clinically translatable framework for rapid, large-scale screening, addressing critical gaps in TET management through metabolic-driven stratification.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2522028123","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T17:06:26Z","timestamp":1769792786000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":5,"title":["Fe metal\u2013organic framework\u2013derived heterojunction for metabolic diagnosis of thymic epithelial tumor"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6531-2539","authenticated-orcid":false,"given":"Yongpeng","family":"Liang","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry, Guangdong Basic Research Center of Excellence for Functional Molecular 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Han L. Huang Data from \u201cFe metal\u2013organic framework\u2013derived heterojunction for metabolic diagnosis of thymic epithelial tumor.\u201d GitHub. https:\/\/github.com\/Haochen-Han\/PNAS-TETs-SMFs. 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