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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:p>\n                    Breast cancer is the leading cause of death in women under 50. The majority of breast cancers are estrogen receptor \u03b1-positive (ER+) and are commonly treated with hormonal therapies such as tamoxifen that inhibit ER activity. The\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    tumor suppressor gene, encoding the p53 protein, is the most frequently mutated gene in breast cancer, and\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    mutations are associated with diminished tamoxifen response and worse prognosis for breast cancer patients. Here, we report that in breast cancer cells p53 and ER cooperate to regulate the transcription of a set of genes encoding chromatin modifiers. The net result is a global increase in H3K4me3 and decrease in H3K9me3 chromatin marks. The resultant \u201copen\u201d chromatin is associated with increased transcription of luminal cell identity genes and enhanced tamoxifen sensitivity. Conversely, diminished p53 control of these chromatin modulators is associated with the evolution of tamoxifen resistance and cancer stem cell properties.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2522646122","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:38:17Z","timestamp":1761759497000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer"],"prefix":"10.1073","volume":"122","author":[{"given":"Yael","family":"Aylon","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-519X","authenticated-orcid":false,"given":"Noa","family":"Furth","sequence":"additional","affiliation":[{"name":"Department of Immunology and Regenerative Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"Pirona","sequence":"additional","affiliation":[{"name":"Department of Systems Immunology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Lavie","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Hassin","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-2806","authenticated-orcid":false,"given":"Nuno","family":"Padr\u00e3o","sequence":"additional","affiliation":[{"name":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Steinmetz","sequence":"additional","affiliation":[{"name":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital","family":"Sarusi-Potuguez","sequence":"additional","affiliation":[{"name":"Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Fellus-Alyagor","sequence":"additional","affiliation":[{"name":"Department of Veterinary Resources, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Shimoni","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bareket","family":"Dassa","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Core Facilities, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9823-7289","authenticated-orcid":false,"given":"Wilbert","family":"Zwart","sequence":"additional","affiliation":[{"name":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3718-593X","authenticated-orcid":false,"given":"Efrat","family":"Shema","sequence":"additional","affiliation":[{"name":"Department of Immunology and Regenerative Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-7172","authenticated-orcid":false,"given":"Moshe","family":"Oren","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science","place":["Rehovot, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_3_4_1_2","article-title":"The complex landscape of luminal breast cancer","volume":"32","author":"Lutz C.","year":"2025","unstructured":"C. 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