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These mesoscale correlations undergo collective relaxation on microsecond to millisecond timescales, as directly resolved by XPCS through the decay of ferritin density fluctuations. The magnitude of this depends sensitively on crowder molecular weight and type. Normalizing the crowder concentration by\n                    <jats:italic toggle=\"yes\">c<\/jats:italic>\n                    * reveals scaling behavior of ferritin self-diffusion with a crossover near 2\n                    <jats:italic toggle=\"yes\">c<\/jats:italic>\n                    *, marking a transition from depletion-enhanced mobility to viscosity-dominated slowing. Our results demonstrate that bulk properties alone are insufficient to describe protein dynamics in crowded solutions, highlighting the need to include polymer-specific interactions and depletion theory in models of crowded environments.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2524733123","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:28:06Z","timestamp":1785342486000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Depletion-induced interactions modulate nanoscale protein diffusion in polymeric crowder solutions"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1925-9860","authenticated-orcid":false,"given":"Michelle","family":"Dargasz","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02azyry73","id-type":"ROR","asserted-by":"publisher"}],"name":"Department Physik, Universit\u00e4t Siegen","place":["Siegen, 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