{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:53:16Z","timestamp":1785412396299,"version":"3.56.0"},"reference-count":96,"publisher":"National Academy of Sciences","issue":"29","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the NIH","doi-asserted-by":"publisher","award":["R35 GM122523"],"award-info":[{"award-number":["R35 GM122523"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["INCa-DGOS-Inserm 12560"],"award-info":[{"award-number":["INCa-DGOS-Inserm 12560"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. 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Molecular dynamics simulations predicted that mutation to His, but not Asn, not only destabilizes the active site, but stabilizes the substrate-binding helices in the kinase C-lobe to potentially promote aberrant interactions. Supporting this, phosphoproteomic, proximity labeling, and coimmunoprecipitation mass spectrometry data from cells overexpressing PKC\u03b1\n                    <jats:sub>D463H<\/jats:sub>\n                    identified both altered phosphorylation of substrates and binding to multiple proteins involved in cell\u2013cell junctions compared to WT enzyme. Last, single nuclei RNAseq established that ChG derives from specialized tanycytes. Our data reveal that this disease-defining, fully penetrant mutation converts PKC\u03b1 into a pseudokinase with novel scaffold functions that uniquely rewire the cellular interactome to impair cell junction function.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2524934123","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:01:17Z","timestamp":1783969277000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Pseudokinase-converting mutation in protein kinase C alpha drives chordoid glioma by pathway rewiring"],"prefix":"10.1073","volume":"123","author":[{"given":"Charlotte","family":"Bellamy","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02en5vm52","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut du Cerveau, Paris Brain Institute (ICM, CNRS, Inria, Inserm), \u00e9quipe labellis\u00e9e Ligue Nationale contre le Cancer, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-7256","authenticated-orcid":false,"given":"Hannah","family":"Tovell","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0168r3w48","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, University of California, San Diego","place":["La Jolla"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany H.","family":"Kao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0168r3w48","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, University of California, San Diego","place":["La Jolla"]},{"name":"Biomedical Sciences Graduate Program, University of California at San Diego","place":["La Jolla"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandr","family":"Kornev","sequence":"additional","affiliation":[{"name":"LSP Consulting LLC","place":["Temecula"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5526-6639","authenticated-orcid":false,"given":"Quentin","family":"Letourneur","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02en5vm52","id-type":"ROR","asserted-by":"publisher"}],"name":"Assistance Publique - 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