{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:42:31Z","timestamp":1791852151336,"version":"4.3.4"},"reference-count":32,"publisher":"National Academy of Sciences","issue":"26","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,12,24]]},"abstract":"<jats:p>\n                    We present the complete genome sequence of uropathogenic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , strain CFT073. A three-way genome comparison of the CFT073, enterohemorrhagic\n                    <jats:italic>E. coli<\/jats:italic>\n                    EDL933, and laboratory strain MG1655 reveals that, amazingly, only 39.2% of their combined (nonredundant) set of proteins actually are common to all three strains. The pathogen genomes are as different from each other as each pathogen is from the benign strain. The difference in disease potential between O157:H7 and CFT073 is reflected in the absence of genes for type III secretion system or phage- and plasmid-encoded toxins found in some classes of diarrheagenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    . The CFT073 genome is particularly rich in genes that encode potential fimbrial adhesins, autotransporters, iron-sequestration systems, and phase-switch recombinases. Striking differences exist between the large pathogenicity islands of CFT073 and two other well-studied uropathogenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    strains, J96 and 536. Comparisons indicate that extraintestinal pathogenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    arose independently from multiple clonal lineages. The different\n                    <jats:italic>E. coli<\/jats:italic>\n                    pathotypes have maintained a remarkable synteny of common, vertically evolved genes, whereas many islands interrupting this common backbone have been acquired by different horizontal transfer events in each strain.\n                  <\/jats:p>","DOI":"10.1073\/pnas.252529799","type":"journal-article","created":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T13:14:48Z","timestamp":1040649288000},"page":"17020-17024","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1314,"title":["Extensive mosaic structure revealed by the complete genome sequence of uropathogenic\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1073","volume":"99","author":[{"given":"R. A.","family":"Welch","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Laboratory of Genetics, Genome Center of Wisconsin, and Animal Health and Biological Sciences, University of Wisconsin, Madison, WI 53706; and Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Burland","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Laboratory of Genetics, Genome Center of Wisconsin, and Animal Health and Biological Sciences, University of Wisconsin, Madison, WI 53706; and Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"G.","family":"Plunkett","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Laboratory of Genetics, Genome Center of Wisconsin, and Animal Health and Biological Sciences, University of Wisconsin, Madison, WI 53706; and Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Redford","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Laboratory of Genetics, Genome Center of Wisconsin, and Animal Health and Biological Sciences, University of Wisconsin, Madison, WI 53706; and Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Roesch","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Laboratory of Genetics, Genome Center of Wisconsin, and Animal Health and Biological Sciences, University of Wisconsin, Madison, WI 53706; and Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Rasko","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Laboratory of Genetics, Genome Center of Wisconsin, and Animal Health and Biological Sciences, University of Wisconsin, Madison, WI 53706; and Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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