{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:18:26Z","timestamp":1788286706315,"version":"build-2803163510"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"36","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874313"],"award-info":[{"award-number":["81874313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273938"],"award-info":[{"award-number":["82273938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81922068"],"award-info":[{"award-number":["81922068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900055"],"award-info":[{"award-number":["81900055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304511"],"award-info":[{"award-number":["82304511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304510"],"award-info":[{"award-number":["82304510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473935"],"award-info":[{"award-number":["82473935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"scientific research project of the hunan provincial health commision","award":["B202302078468"],"award-info":[{"award-number":["B202302078468"]}]},{"name":"scientific research project of the hunan provincial health commision","award":["B202302078452"],"award-info":[{"award-number":["B202302078452"]}]},{"name":"scientific research project of the hunan provincial health commision","award":["20254893"],"award-info":[{"award-number":["20254893"]}]},{"DOI":"10.13039\/501100004735","name":"HSTD | Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40349"],"award-info":[{"award-number":["2023JJ40349"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"HSTD | Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40352"],"award-info":[{"award-number":["2023JJ40352"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Science and Technology Commission of China","award":["cstc2021jcyj-jqX0006"],"award-info":[{"award-number":["cstc2021jcyj-jqX0006"]}]},{"name":"Chongqing Science and Technology Commission of China","award":["CSTB2022NSCQ-MSX1491"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1491"]}]},{"name":"Guangdong Association of Clinical Trials (GACT)\/ Chinese Thoracic Oncology Group (CTONG), Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer","award":["CTONG-YC20210104"],"award-info":[{"award-number":["CTONG-YC20210104"]}]},{"name":"Chongqing Science and Technology Commission of China","award":["CSTB2024NSCQ-JQX0041"],"award-info":[{"award-number":["CSTB2024NSCQ-JQX0041"]}]},{"name":"Chongqing Science and Technology Commission of China","award":["CSTB2023TIAD-STX007"],"award-info":[{"award-number":["CSTB2023TIAD-STX007"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:p>\n                    The transcriptional regulator Rbp-J\u03ba is a pivotal molecular switch in Notch signaling; however, its cell-intrinsic role in natural killer (NK) cell maturation and migration remains incompletely understood. Here, we demonstrate that NK cell-specific deletion of Rbp-J\u03ba (\n                    <jats:italic toggle=\"yes\">\n                      Ncr1\n                      <jats:sup>iCre<\/jats:sup>\n                    <\/jats:italic>\n                    \u00d7\n                    <jats:italic toggle=\"yes\">\n                      Rbp-J\u03ba\n                      <jats:sup>fl\/fl<\/jats:sup>\n                    <\/jats:italic>\n                    , Rbp-J\u03ba\n                    <jats:sup>\u0394NK<\/jats:sup>\n                    ) impairs NK cell terminal maturation and migration, as evidenced by increased retention of NK cells in bone marrow, a reduced number of circulating NK cells and decreased expression of migration mediators (CD62L, S1pr5, and Cx3cr1). Despite exhibiting an activated phenotype, Rbp-J\u03ba-deficient NK cells fail to control B16F10 lung metastases in vivo because of impaired tissue mobilization. Multiomics (scRNA-seq\/scATAC-seq, bulk ATAC-seq, and CUT&amp;Tag) reveal that Rbp-J\u03ba orchestrates chromatin remodeling in NK cells, suppressing the expression of genes related to NK cell activation and cytotoxicity while promoting the expression of genes involved in ribosome and oxidative phosphorylation. Notably, Rbp-J\u03ba directly binds to the Kruppel-like factor 2 (Klf2) promoter, and loss of Rbp-J\u03ba reduces both the mRNA and protein levels of Klf2. Klf2 overexpression rescues the decreased expression of CD62L and CX3CR1 in Rbp-J\u03ba-deficient NK cells. The cooccupancy of Rbp-J\u03ba and Klf2 at shared genomic loci is confirmed by ChIP\u2013qPCR. In summary, our study reveals that Rbp-J\u03ba acts as a master regulator of NK cell terminal maturation and tissue homing via chromatin reprogramming, with Klf2 acting as its critical downstream transcription factor.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2525481123","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:58:11Z","timestamp":1788285491000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Rbp-J\u03ba controls NK cell late maturation and migration via chromatin landscape remodeling"],"prefix":"10.1073","volume":"123","author":[{"given":"Hongyan","family":"Peng","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"name":"Department of Pharmacy, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Wu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Hu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0100-6263","authenticated-orcid":false,"given":"Xiaoyu","family":"Deng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Huang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"The School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Xiong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglan","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyang","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Gong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Song","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjie","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Yu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04gyf1771","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Hematology and Oncology, Department of Medicine, School of Medicine, University of California","place":["Irvine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghui","family":"Xiao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Deng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatrics Research Institute of Hunan Province, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]},{"id":[{"id":"https:\/\/ror.org\/03e207173","id-type":"ROR","asserted-by":"publisher"}],"name":"The School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Zhong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/023rhb549","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Oncology, Fuling Hospital of Traditional Chinese Medicine, Chongqing University of Chinese Medicine","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5488-8576","authenticated-orcid":false,"given":"Youcai","family":"Deng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University","place":["Chongqing, China"]},{"id":[{"id":"https:\/\/ror.org\/05w21nn13","id-type":"ROR","asserted-by":"publisher"}],"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00558-3"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0061-z"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06945-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01058-z"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.07.005"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01439-z"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00091-3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2009"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.04.020"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701675"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01252"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002273"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900998"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-23-0359"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-23-0339"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202205-0848OC"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.02.034"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.680611"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521491113"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1523"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-297101"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2023.09.004"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01502"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.003"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2020.12.003"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128310"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07277-9"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.006"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv145"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.036"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13204"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01282-5"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051144"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0336-2"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-02014-7"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42313-3"},{"key":"e_1_3_4_42_2","unstructured":"Y. Deng Rbp-JK controls NK cell late maturation and migration via global chromatin landscape remodeling. Genome Sequence Archive (GSA). https:\/\/ngdc.cncb.ac.cn\/gsa\/browse\/CRA029947. Deposited 9 September 2025."},{"key":"e_1_3_4_43_2","unstructured":"L. Yang ImmGen ULI: Systemwide RNA-seq profiles (#1). Gene ExpressionOmnibus (GEO). https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE109125. Deposited 12 January 2018."},{"key":"e_1_3_4_44_2","unstructured":"V. Male Comparison of NK cell developmental stages in bone marrow ofTbx21 WT versus KO mice. Gene Expression Omnibus (GEO). https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE122874. Deposited 23 November 2018."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2525481123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:58:33Z","timestamp":1788285513000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2525481123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":44,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2026,9,8]]}},"alternative-id":["10.1073\/pnas.2525481123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2525481123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2525481123"}}