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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:p>\n                    Aromatic essential oils (EOs) exhibit anxiolytic properties, yet their neural and molecular mechanisms remain to be understood. Here, we found that citronellal, an EO derived from lemongrass, alleviates stress-related anxiety by modulating vagal tone. We identified transient receptor potential vanilloid 3 (TRPV3) channel in nodose ganglion (NG) as the molecular target of citronellal. TRPV3 was also observed to mediate the antistress effects of the inhaled anesthetic sevoflurane. Both sedatives attenuated acute restraint stress-induced hyperactivity of heart and breath rates via glutamatergic neurotransmission along NG-to-caudal nucleus tractus solitarius (cNTS) pathway. This effect was abolished by surgical vagotomy,\n                    <jats:italic toggle=\"yes\">Trpv3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    , or NG-specific\n                    <jats:italic toggle=\"yes\">Trpv3<\/jats:italic>\n                    knockdown. Cryo-EM structural analysis revealed that sevoflurane occupies a pore-proximal fenestration site, while citronellal binds to the vanilloid site. Re-expression of wild-type TRPV3, but not loss-of-function TRPV3 mutants TRPV3(A560L) or TRPV3(V662A), in\n                    <jats:italic toggle=\"yes\">Trpv3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    NG neurons restored the mouse\u2019s response to both sedatives, thereby modulating heart and respiratory rates. Together, these findings establish peripheral TRPV3 as a multisensory ligand-gated node for vagal modulation of stress responses, and help instruct pathway-specific anxiolytics.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2525757123","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:59:39Z","timestamp":1776355179000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["Vagal nerve TRPV3 regulates sedative-mediated appeasement"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3905-4480","authenticated-orcid":false,"given":"Peiyu","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for 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