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We wondered whether this firing remained stable across lifespan in aging mice. We performed juxtacellular recordings from Purkinje cells in acute cerebellar slices and observed a reduction in the rate of firing in aged animals without changes in firing regularity. To understand whether reduced Purkinje cell firing rate caused impaired motor performance in aged mice, we used chemogenetics to modulate Purkinje cell firing. Reducing Purkinje cell firing rates in young mice impaired motor performance, while elevating Purkinje cell firing rates in aged mice improved motor performance. Our results suggest that Purkinje cell firing rate impacts motor coordination and that the aging-related reduction of Purkinje cell firing rate that we observed contributes to impaired motor coordination and could contribute to declining health span and quality of life in the elderly.<\/jats:p>","DOI":"10.1073\/pnas.2525795122","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:39:29Z","timestamp":1767375569000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":4,"title":["Cerebellar Purkinje cell firing reduction contributes to aging-related declining motor coordination in mice"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-4644","authenticated-orcid":false,"given":"Eviatar","family":"Fields","sequence":"first","affiliation":[{"name":"Integrated Program in Neuroscience, McGill University","place":["Montreal, Canada"]},{"name":"Department of Biology, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben C.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsz Chui Sophia","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nell","family":"Kontowicz","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Dolin","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-6220","authenticated-orcid":false,"given":"Alanna J.","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2307449120"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.024"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2008.139469"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069627"},{"key":"e_1_3_4_5_2","first-page":"771","article-title":"Falls in the elderly","volume":"57","author":"Al-Aama T.","year":"2011","unstructured":"T. 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