{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:58:13Z","timestamp":1788400693488,"version":"build-2803163510"},"reference-count":89,"publisher":"National Academy of Sciences","issue":"11","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022992","name":"CIHR | Clinical Trials Fund, Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["498150"],"award-info":[{"award-number":["498150"]}],"id":[{"id":"10.13039\/100022992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002248","name":"National Multiple Sclerosis Society Michigan Chapter","doi-asserted-by":"publisher","award":["TA-2101-37225"],"award-info":[{"award-number":["TA-2101-37225"]}],"id":[{"id":"10.13039\/100002248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["CRC-2020-00068"],"award-info":[{"award-number":["CRC-2020-00068"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:p>\n                    Meningeal inflammation, as a clinical feature of multiple sclerosis (MS), is associated with worse clinical disease outcomes. In both relapsing and secondary progressive MS and the experimental autoimmune encephalomyelitis (EAE) MS model, the meninges have been found to contain ectopic lymphoid follicles enriched with B cells. The metabolic requirement of meningeal B cell function in MS or EAE is not well elucidated. Using 7-Tesla MRI brain scans of MS patients and leptomeningeal enhancement as a marker, we found a correlation between meningeal inflammation and metabolites of the arginine\/polyamine pathway, a finding recapitulated in EAE. Ornithine Decarboxylase (ODC1), the rate limiting enzyme for polyamine biosynthesis, as well as polyamine metabolism was diminished in the dura meningeal B cells from mice with MOG\n                    <jats:sub>35-55<\/jats:sub>\n                    induced EAE mice as compared to na\u00efve controls. Pharmacological inhibition of ODC1 restricted meningeal T cells but promoted meningeal B cell proliferation. B cell\u2013specific deletion of ODC1 resulted in expansion of B cells with age-associated B cell\u2013like phenotype (CD11c\n                    <jats:sup>+<\/jats:sup>\n                    CD21\/35\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD23\n                    <jats:sup>\u2212<\/jats:sup>\n                    IgD\n                    <jats:sup>\u2212<\/jats:sup>\n                    ), an increase in MOG-specific IgG in the brain, reduction of hippocampal synaptic density, and exacerbated disease in the MOG\n                    <jats:sub>1-125<\/jats:sub>\n                    EAE model. Together, these findings demonstrate a divergent role of polyamines in regulating B and T cell responses in the meninges during autoimmunity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2526147123","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:39:57Z","timestamp":1773423597000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-8369","authenticated-orcid":false,"given":"Jonathan","family":"Zurawski","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Mass General Brigham, Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alara","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Biological Sciences Platform, Sunnybrook Research Institute","place":["Toronto, Canada"]},{"name":"Department of Immunology, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-6376","authenticated-orcid":false,"given":"Martin R.","family":"Profant","sequence":"additional","affiliation":[{"name":"Biological Sciences Platform, Sunnybrook Research Institute","place":["Toronto, Canada"]},{"name":"Department of Immunology, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Biological Sciences Platform, Sunnybrook Research Institute","place":["Toronto, Canada"]},{"name":"Department of Immunology, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Green","sequence":"additional","affiliation":[{"name":"Biological Sciences Platform, Sunnybrook Research Institute","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5586-2014","authenticated-orcid":false,"given":"Yoobhin","family":"Park","sequence":"additional","affiliation":[{"name":"Biological Sciences Platform, Sunnybrook Research Institute","place":["Toronto, Canada"]},{"name":"Department of Immunology, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Cao","sequence":"additional","affiliation":[{"name":"Biological Sciences Platform, Sunnybrook Research Institute","place":["Toronto, Canada"]},{"name":"Department of Immunology, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Paris","sequence":"additional","affiliation":[{"name":"Biological Sciences Platform, Sunnybrook Research Institute","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-501X","authenticated-orcid":false,"given":"Shahamat","family":"Tauhid","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Mass General Brigham, Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youmna","family":"Jalkh","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Mass General Brigham, Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4368-3518","authenticated-orcid":false,"given":"Molly","family":"Quattrucci","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Mass General Brigham, Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-238X","authenticated-orcid":false,"given":"Renxin","family":"Chu","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Mass General Brigham, Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2311-1904","authenticated-orcid":false,"given":"Xingshan","family":"Cao","sequence":"additional","affiliation":[{"name":"Evaluative Clinical Sciences, Sunnybrook Research Institute","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kiss","sequence":"additional","affiliation":[{"name":"Evaluative Clinical Sciences, Sunnybrook Research Institute","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-4422","authenticated-orcid":false,"given":"Tanuja","family":"Chitnis","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Mass General Brigham, Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Weiner","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Mass General Brigham, Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary B.","family":"Clish","sequence":"additional","affiliation":[{"name":"Broad Institute of Massachusetts Institute of Technology and Harvard","place":["Cambridge"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-5534","authenticated-orcid":false,"given":"Rohit","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Mass General Brigham, Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3084-6093","authenticated-orcid":false,"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Biological Sciences Platform, Sunnybrook Research Institute","place":["Toronto, Canada"]},{"name":"Department of Immunology, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh641"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm038"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr182"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws189"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12444"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001587"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001286"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.102939"},{"key":"e_1_3_4_9_2","first-page":"620","article-title":"Leptomeningeal contrast enhancement is related to focal cortical thinning in relapsing-remitting multiple sclerosis: A cross-sectional MRI study","volume":"40","author":"Bergsland N.","year":"2019","unstructured":"N. Bergsland , Leptomeningeal contrast enhancement is related to focal cortical thinning in relapsing-remitting multiple sclerosis: A cross-sectional MRI study. Am. J. Neuroradiol. 40, 620\u2013625 (2019).","journal-title":"Am. J. Neuroradiol."},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519885106"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4237"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab045"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2004.tb00049.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200185"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.010"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.87234"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.10.015"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2023174118"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49259-0"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adn2784"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02102-0"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2025.02.015"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110278"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76012"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.02.015"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","unstructured":"C. Wang The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity. Cell Rep 44 115799 (2025).","DOI":"10.1016\/j.celrep.2025.115799"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.068"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3704"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.001"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.05.045"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108333"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-024-01690-6"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI153436"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0598-4"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.04.010"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.02.012"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01098-2"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104242"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00760"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113488"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.750301"},{"key":"e_1_3_4_42_2","first-page":"1933","article-title":"Age-associated B cells: A T-bet-dependent effector with roles in protective and pathogenic immunity","volume":"1950","author":"Rubtsova K.","year":"2015","unstructured":"K. Rubtsova, A. V. Rubtsov, M. P. Cancro, P. Marrack, Age-associated B cells: A T-bet-dependent effector with roles in protective and pathogenic immunity. J. Immunol. Baltim. Md. 1950, 1933\u20131937 (2015).","journal-title":"J. Immunol. Baltim. Md."},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221346"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-092419-031130"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12380"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91250"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04433-9"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.453"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202977109"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8994-2_10"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312348110"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847641"},{"key":"e_1_3_4_53_2","doi-asserted-by":"crossref","unstructured":"C. Wang Metabolic and epigenomic regulation of Th17\/Treg balance by the polyamine pathway. bioRxiv [Preprint] (2020). https:\/\/doi.org\/10.1101\/2020.01.23.911966.","DOI":"10.1101\/2020.01.23.911966"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06487-8"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.06.026"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26448"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25429"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa249"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.007"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05111-3"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614958114"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.003"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0116"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(89)90171-7"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111544"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.08.005"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330530"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331462"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf8531"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0056-8"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt8199"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade6844"},{"key":"e_1_3_4_73_2","first-page":"1023","article-title":"Cutting edge: IL-4, IL-21, and IFN-\u03b3 interact to govern T-bet and CD11c expression in TLR-activated B cells","volume":"1950","author":"Naradikian M. S.","year":"2016","unstructured":"M. S. Naradikian , Cutting edge: IL-4, IL-21, and IFN-\u03b3 interact to govern T-bet and CD11c expression in TLR-activated B cells. J. Immunol. Baltim. Md. 1950, 1023\u20131028 (2016).","journal-title":"J. Immunol. Baltim. Md."},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.03.004"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/5532"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac233"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-76969-8"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8373"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020337"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914905"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1530929"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.09.003"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100361"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr597"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005752"},{"key":"e_1_3_4_86_2","unstructured":"The igraph software package for complex network research. BibSonomy. https:\/\/www.bibsonomy.org\/bibtex\/2a3db966c7a0ce1715c56ce04c806afd9\/yourwelcome."},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102119"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.158144"},{"key":"e_1_3_4_89_2","unstructured":"K. Cao C. Wang Replication Data for: ODC1 Restricts Meningeal B Cell Age-Associated-like Phenotype and Function in Multiple Sclerosis: A Human and Experimental Study. Borealis. https:\/\/doi.org\/10.5683\/SP3\/L2JLO0. Deposited 27 February 2026."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2526147123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:40:29Z","timestamp":1773423629000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2526147123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":89,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,3,17]]}},"alternative-id":["10.1073\/pnas.2526147123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2526147123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"assertion":[{"value":"2025-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2526147123"}}