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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,4,14]]},"abstract":"<jats:p>\n                    How living organisms utilize physical mechanisms to sense their environments and make informed decisions is an open question at the interface of biology and physics. In filamentous organisms like fungal hyphae, the decisions are taken by their growing tip cells and later imprinted onto the rest of the multicellular filament. Here we report on the growth and pathfinding of hyphae from the opportunistic fungal pathogen\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    , whose ability to cross intestinal epithelial layers is associated to severe systemic infections in humans. It has been sporadically reported that\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    \u2019s hyphae display helical growth inside or on top of agar gels, helicity turning in the latter case into two-dimensional oscillatory shapes. We provide an extended description of oscillatory\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    hyphal growth modalities, revealed under various physical confinements thanks to the use of dedicated microfluidic devices and quantitative time-lapse imaging-based analysis. These include sudden sliding events accompanied by curvature switching of the tip portion, resulting in a final oscillatory morphology of the entire filament, and stable curved tips moving against vertical microfluidic channel\u2019s walls. These behaviors are unified under the formalism of growing squeezed helices, in which the final hyphal curved shapes result from an elastic energy minimization of a spatially confined helical portion at the tip followed by a continuous solidification front. Ultimately, the combination of our experimental results and theoretical framework provides an insight into the penetration strategy of\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    hyphae, which is essential for the virulence of this fungal microorganism.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2526262123","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:34:22Z","timestamp":1775842462000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Snooping helices: The elastic path finding algorithm of growing hyphae"],"prefix":"10.1073","volume":"123","author":[{"given":"Antoine","family":"Rittaud","sequence":"first","affiliation":[{"name":"Institut Charles Sadron","place":["BP, France"]},{"name":"Universit\u00e9 de Strasbourg","place":["BP, France"]},{"name":"CNRS","place":["BP, France"]},{"name":"23 rue du Loess","place":["BP, France"]},{"name":"Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]},{"name":"CNRS","place":["Paris, France"]},{"name":"Laboratoire Interdisciplinaire des Energies de Demain","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Couttenier","sequence":"additional","affiliation":[{"name":"Institut Curie","place":["Paris, France"]},{"name":"Universit\u00e9 Paris Sciences et Lettres","place":["Paris, France"]},{"name":"Sorbonne Universit\u00e9","place":["Paris, France"]},{"name":"CNRS","place":["Paris, France"]},{"name":"Physics of Cells and Cancer","place":["Paris, France"]},{"name":"Institut Pasteur","place":["Paris, France"]},{"name":"Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]},{"name":"INRAE","place":["Paris, France"]},{"name":"USC2019","place":["Paris, France"]},{"name":"Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-4825","authenticated-orcid":false,"given":"Sophie","family":"Bachellier-Bassi","sequence":"additional","affiliation":[{"name":"Institut Pasteur","place":["Paris, France"]},{"name":"Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]},{"name":"INRAE","place":["Paris, France"]},{"name":"USC2019","place":["Paris, France"]},{"name":"Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-3886","authenticated-orcid":false,"given":"Christophe","family":"d\u2019Enfert","sequence":"additional","affiliation":[{"name":"Institut Pasteur","place":["Paris, France"]},{"name":"Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]},{"name":"INRAE","place":["Paris, France"]},{"name":"USC2019","place":["Paris, France"]},{"name":"Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9400-5782","authenticated-orcid":false,"given":"Igor M.","family":"Kuli\u0107","sequence":"additional","affiliation":[{"name":"Institut Charles Sadron","place":["BP, France"]},{"name":"Universit\u00e9 de Strasbourg","place":["BP, France"]},{"name":"CNRS","place":["BP, France"]},{"name":"23 rue du Loess","place":["BP, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-1067","authenticated-orcid":false,"given":"Catherine","family":"Villard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]},{"name":"CNRS","place":["Paris, France"]},{"name":"Laboratoire Interdisciplinaire des Energies de Demain","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.122.098101"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-011-0778-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.1.221"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.131.178401"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3732\/ajb.1200314"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018940118"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","unstructured":"M. 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