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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,1,13]]},"abstract":"<jats:p>\n                    Ductal carcinoma in situ (DCIS) is a precursor mammary lesion characterized by abnormal epithelial cells in mammary ducts that remain confined to the luminal space. Not all DCIS becomes invasive, and no strategy currently exists in patients to stratify indolent DCIS from DCIS at risk of progression. Several studies of human DCIS and breast cancer suggest that\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    mutations occur early in DCIS. However,\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    mutation alone is insufficient for DCIS formation or transformation to invasive disease. Using an autochthonous somatic mouse model of\n                    <jats:italic toggle=\"yes\">\n                      Trp53\n                      <jats:sup>R245W<\/jats:sup>\n                    <\/jats:italic>\n                    induced breast cancer (equivalent to the\n                    <jats:italic toggle=\"yes\">\n                      TP53\n                      <jats:sup>R248W<\/jats:sup>\n                    <\/jats:italic>\n                    hotspot mutation in humans), we identified DCIS lesions. Through exome sequencing and low-pass whole-genome sequencing, we identified additional genomic changes shared between DCIS and invasive tumors. This comparison nominated seven murine candidate genes, with eight human orthologs. We assessed the cooperativity of these genes with mutant\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    in human breast cells using acinar morphogenesis and migration assays. Overexpression of\n                    <jats:italic toggle=\"yes\">TMEM267<\/jats:italic>\n                    , which encodes a transmembrane protein overexpressed in 22% of\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    missense mutant breast cancer cases, in cells with mutant\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    caused a significant increase in the filled duct, DCIS-like phenotype. We nominate\n                    <jats:italic toggle=\"yes\">TMEM267<\/jats:italic>\n                    as a cooperating event with mutant\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    in DCIS progression.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2526544123","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:03:48Z","timestamp":1767899028000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Elucidating cooperative genetic events in DCIS progression in mutant\n                    <i>p53<\/i>\n                    \u2013driven breast cancer"],"prefix":"10.1073","volume":"123","author":[{"given":"Rhiannon L.","family":"Morrissey","sequence":"first","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences","place":["Houston"]},{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy M.","family":"McDaniel","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-3290","authenticated-orcid":false,"given":"Gilda P.","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, The University of Texas MD Anderson Cancer Center","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitheera","family":"V","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences","place":["Houston"]},{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhi","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly R. 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