{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:29:31Z","timestamp":1787005771128,"version":"build-2736575974"},"reference-count":71,"publisher":"National Academy of Sciences","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"USDA | Agricultural Research Service","doi-asserted-by":"publisher","award":["A Systematic Research Approach to Responsive Agriculture for the Advancement of Health"],"award-info":[{"award-number":["A Systematic Research Approach to Responsive Agriculture for the Advancement of Health"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:p>\n                    Folate-mediated one-carbon metabolism is implicated in several pathologies including neural tube defects (NTDs), cancer, and neurodegenerative disorders, whereas diabetes is associated with NTDs and peripheral neuropathy (PN). The development of peripheral neuropathy was assessed in\n                    <jats:italic toggle=\"yes\">\n                      Shmt1\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      and Shmt1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice, which are models of human folic acid\u2013responsive NTDs, and diabetic (\n                    <jats:italic toggle=\"yes\">\n                      Lepr\n                      <jats:sup>db<\/jats:sup>\n                    <\/jats:italic>\n                    ) mice to determine whether NTDs and PN have a shared etiology. From 6 wk of age, male and female mice with reduced\n                    <jats:italic toggle=\"yes\">Shmt1<\/jats:italic>\n                    expression exhibited PN, with greater severity in females compared to males. The neuropathic progression was distinct from diabetic peripheral neuropathy (DPN) observed in\n                    <jats:italic toggle=\"yes\">\n                      Lepr\n                      <jats:sup>db<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Excess dietary folic acid prevented PN in both\n                    <jats:italic toggle=\"yes\">Shmt1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    and\n                    <jats:italic toggle=\"yes\">\n                      Lepr\n                      <jats:sup>db\/db<\/jats:sup>\n                    <\/jats:italic>\n                    mice, whereas dietary uridine caused demyelinating PN in mice independent of genotype and folate status. The transcriptome from L3-L5 dorsal root ganglia (DRG) exhibited distinct sex-specific differences in glial cell gene expression when comparing\n                    <jats:italic toggle=\"yes\">\n                      Shmt1\n                      <jats:sup>+\/+<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">\n                      Shmt1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice. DRG sensory neurons exhibited changes in the expression of solute carriers and ion channels involved in nociception, neurotransmission, and structural support. We conclude that reduced thymidylate synthesis causes folic acid\u2013responsive NTDs and PN in mice and that diabetes sensitizes mice to folic acid\u2013responsive PN. Diabetes induces a special nutritional requirement for high intake of folic acid to prevent PN.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2528095123","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:39:09Z","timestamp":1767375549000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-2920","authenticated-orcid":false,"given":"Joydeep","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Florida State University","place":["Tallahassee"]},{"name":"Institute for Connecting Nutrition and Health, Florida State University","place":["Tallahassee"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-4571","authenticated-orcid":false,"given":"Adhideb","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Functional Genomics Center Zurich, ETH Zurich and University of Zurich","place":["Zurich, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice B.","family":"Awuah","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University","place":["Ithaca"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally P.","family":"Stabler","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado, Anschutz Medical Campus","place":["Aurora"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-5180","authenticated-orcid":false,"given":"Martha S.","family":"Field","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University","place":["Ithaca"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regan L.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Institute for Connecting Nutrition and Health, Florida State University","place":["Tallahassee"]},{"name":"Department of Behavioral and Social Medicine, Florida State University","place":["Tallahassee"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7546-3814","authenticated-orcid":false,"given":"Patrick J.","family":"Stover","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Florida State University","place":["Tallahassee"]},{"name":"Institute for Connecting Nutrition and Health, Florida State University","place":["Tallahassee"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2018.10.006"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1694747"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1212-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98565-w"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S274122"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-89835-5.00013-2"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914628107"},{"key":"e_1_3_4_8_2","first-page":"15","article-title":"Influence of selected dietary components on the functioning of the human nervous system","volume":"69","author":"Wendo\u0142owicz A.","year":"2018","unstructured":"A. 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