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In this study, we demonstrate that\n                    <jats:italic toggle=\"yes\">Arabidopsis<\/jats:italic>\n                    ADFs exhibit a moonlighting function in the nucleus, where they interact with transcriptional machinery to regulate the transcriptome during both the resting state and the immune responses. We show that ADF2\/3\/4 have redundant functions in defense against virulent and avirulent\n                    <jats:italic toggle=\"yes\">Pseudomonas syringae<\/jats:italic>\n                    . Notably, it is nuclear\u2014rather than cytosolic\u2014ADFs that majorly contribute to defense against\n                    <jats:italic toggle=\"yes\">P. syringae<\/jats:italic>\n                    and mediate proimmune transcription. Mechanistically, we demonstrate that nuclear ADFs interact with transcription factors, histone complexes, and other components of the transcriptional machinery. Specifically, ADF2\/3\/4 can form a complex with WRKY transcription factors, such as WRKY22\/29\/48, thereby directly regulating WRKY activity to shape the proimmune transcriptome. In summary, our study reveals that ADFs moonlight as direct regulators of transcription factors, mediating a broad range of nuclear-cytoplasmic regulation in plant immunity and potentially other biological processes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2530072123","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:58:11Z","timestamp":1788285491000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Actin depolymerization factor (ADF) moonlighting: Nuclear immune regulation by interacting with WRKY transcription factors and shaping the transcriptome"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-3543","authenticated-orcid":false,"given":"Pai","family":"Li","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hs6h993","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Plant, Soil and Microbial 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