{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:07:15Z","timestamp":1785424035724,"version":"3.56.0"},"reference-count":55,"publisher":"National Academy of Sciences","issue":"26","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM138493"],"award-info":[{"award-number":["GM138493"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS095989"],"award-info":[{"award-number":["NS095989"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL122010"],"award-info":[{"award-number":["HL122010"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM141933"],"award-info":[{"award-number":["GM141933"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM151766"],"award-info":[{"award-number":["GM151766"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | NIH","doi-asserted-by":"publisher","award":["1S10OD021630"],"award-info":[{"award-number":["1S10OD021630"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA68485"],"award-info":[{"award-number":["CA68485"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK20593"],"award-info":[{"award-number":["DK20593"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK58404"],"award-info":[{"award-number":["DK58404"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK59637"],"award-info":[{"award-number":["DK59637"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["EY08126"],"award-info":[{"award-number":["EY08126"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA68485"],"award-info":[{"award-number":["P30 CA68485"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | NIH","doi-asserted-by":"publisher","award":["UL1TR00044"],"award-info":[{"award-number":["UL1TR00044"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS119505"],"award-info":[{"award-number":["NS119505"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["26POST1542927"],"award-info":[{"award-number":["26POST1542927"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | NIH","doi-asserted-by":"publisher","award":["S10OD034362"],"award-info":[{"award-number":["S10OD034362"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>Membrane order and fluidity influence many biological processes. However, tools to manipulate membranes under physiological conditions have been limited. In the process of high-throughput screening for molecules that shift the phase partitioning between ordered and disordered membrane phases of the tetraspan membrane protein peripheral myelin protein 22 (PMP22), we identified two chemically similar compounds, VU0615562 and VU0619195, that shift PMP22 toward the disordered phase and destabilize the \u201clipid raft\u201d-like ordered phase. Follow-up experiments showed that this latter activity is, counterintuitively, enhanced by the presence of PMP22, which normally stabilizes the ordered phase. Biophysical studies indicate that these compounds reduce raft stability through a mechanism that involves both direct interactions with proteins and the disruption of lipid packing. We further observed that acute treatment of live cells with VU0619195 modulated membrane fluidity and TRPM8 channel function while both compounds altered KCNQ1 channel activity, providing examples of practical applications for these compounds. These protein-enhanced raft modulators reveal distinct lipid and protein-based forces that destabilize membrane order and may be useful as pharmacological tools for manipulating and probing the biological roles of ordered membrane domains in cells.<\/jats:p>","DOI":"10.1073\/pnas.2530579123","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:06:47Z","timestamp":1782238007000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Protein-enhanced small molecule disruptors of ordered membrane domains"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-0598","authenticated-orcid":false,"given":"Katherine M.","family":"Stefanski","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Vanderbilt University School of Medicine","place":["Nashville"]},{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Structural Biology, Vanderbilt University School of Medicine","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-5916","authenticated-orcid":false,"given":"Geoffrey C.","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Vanderbilt University School of Medicine","place":["Nashville"]},{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Structural Biology, Vanderbilt University School of Medicine","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-160X","authenticated-orcid":false,"given":"Dustin D.","family":"Luu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03efmqc40","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Molecular Sciences, Arizona State University","place":["Tempe"]},{"id":[{"id":"https:\/\/ror.org\/03efmqc40","id-type":"ROR","asserted-by":"publisher"}],"name":"The Virginia G. Piper Biodesign Center for Personalized Diagnostics, Arizona State University","place":["Tempe"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6299-2354","authenticated-orcid":false,"given":"Kelvin K.","family":"Fosu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03efmqc40","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Molecular Sciences, Arizona State University","place":["Tempe"]},{"id":[{"id":"https:\/\/ror.org\/03efmqc40","id-type":"ROR","asserted-by":"publisher"}],"name":"The Virginia G. Piper Biodesign Center for Personalized Diagnostics, Arizona State University","place":["Tempe"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Guadarrama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Feinberg School of Medicine, Northwestern University","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Hutchison","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03v76x132","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, Yale University School of Medicine","place":["New Haven"]},{"id":[{"id":"https:\/\/ror.org\/03v76x132","id-type":"ROR","asserted-by":"publisher"}],"name":"Yale Cancer Biology Institute, Yale University School of Medicine","place":["West Haven"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9374-5006","authenticated-orcid":false,"given":"Nilabh","family":"Saksena","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Vanderbilt University School of Medicine","place":["Nashville"]},{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Structural Biology, Vanderbilt University School of Medicine","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3085-7083","authenticated-orcid":false,"given":"Yelyzaveta","family":"Zuy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Vanderbilt University School of Medicine","place":["Nashville"]},{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Structural Biology, Vanderbilt University School of Medicine","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Fisch","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Vanderbilt University School of Medicine","place":["Nashville"]},{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Structural Biology, Vanderbilt University School of Medicine","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6522-323X","authenticated-orcid":false,"given":"Thomas P.","family":"Hasaka","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Vanderbilt University School of Medicine","place":["Nashville"]},{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Vanderbilt Institute of Chemical Biology, High-Throughput Screening Facility, Vanderbilt University School of Medicine","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Bauer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Vanderbilt University School of Medicine","place":["Nashville"]},{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Vanderbilt Institute of Chemical Biology, High-Throughput Screening Facility, Vanderbilt University School of Medicine","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-966X","authenticated-orcid":false,"suffix":"Jr.","given":"Alfred L.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Feinberg School of Medicine, Northwestern University","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6567-9059","authenticated-orcid":false,"given":"Anne K.","family":"Kenworthy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0153tk833","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Membrane and Cell Physiology, University of Virginia School of Medicine","place":["Charlottesville"]},{"id":[{"id":"https:\/\/ror.org\/0153tk833","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine","place":["Charlottesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-5578","authenticated-orcid":false,"given":"Wade D. Van","family":"Horn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03efmqc40","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Molecular Sciences, Arizona State University","place":["Tempe"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-2862","authenticated-orcid":false,"given":"Charles R.","family":"Sanders","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Vanderbilt University School of Medicine","place":["Nashville"]},{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Structural Biology, Vanderbilt University School of Medicine","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041395"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2022.184114"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01268-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.1041961"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01596"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R000005200"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12617"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom14030362"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2004.0181.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-022-10448-3"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000508117"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-025-01874-8"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100719"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.059"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c01058"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.0c03028"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.4.929"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2019.12.040"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2021.100155"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-015-0069-3"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01097"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjsbx.2024.100100"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.072884"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00652-9"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature719"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2003.11.007"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30679"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711900"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807228200"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.4161\/cl.23967"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c09435"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22265"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700168"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22570"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208327200"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp400204y"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23840"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-02-0142"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110803"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2942-18.2019"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20231359"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.100.042410"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1028"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-07-0536"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4125.656"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1042\/bse0570135"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3003-1"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174621"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2008.08.007"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.16"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.01.009"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-024-01849-6"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318245e0c5"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-024-00319-y"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01876-4"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2530579123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:08:19Z","timestamp":1782238099000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2530579123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":55,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2026,6,30]]}},"alternative-id":["10.1073\/pnas.2530579123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2530579123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"assertion":[{"value":"2025-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2530579123"}}