{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:28:51Z","timestamp":1787851731937,"version":"build-2784847793"},"reference-count":135,"publisher":"National Academy of Sciences","issue":"35","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["740.018.013"],"award-info":[{"award-number":["740.018.013"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>\n                    Cell competition in multicellular organisms has been shown to play a critical role during the development of organisms, cancer progression, and in the establishment and maintenance of tissue homeostasis. Various mechanisms of cell competition have been identified, including active elimination via mechanical forces or induced apoptosis, as well as competition for nutrients and other beneficial factors. A recent experiment demonstrated hallmarks of cell competition, associated with cell cycle dynamics, between liver progenitor cells and colorectal cancer cells [A. Krotenberg Garcia et al.,\n                    <jats:italic toggle=\"yes\">iScience<\/jats:italic>\n                    <jats:bold>27<\/jats:bold>\n                    , 109718 (2024)]. However, a mechanistic explanation for this form of competition remains lacking. Here, we present a mean-field model of competition for signaling ligands, coupled with cell cycle dynamics, to provide such an understanding. Our model captures the salient features of the experiment, including population dynamics and cell cycle variations. We demonstrate that secretion of a beneficial factor by cells, coupled with the enhanced uptake efficiency of cancer cells, suffices to reproduce the experimental outcome. Our model, reminiscent of competition for secreted growth factors, provides insight into the minimal level of complexity required to achieve the observed competitive outcome as well as its link to cell cycle dynamics. It can also serve as a general framework for studying biological populations with growth-stage-dependent competition over consumer-produced products.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2531078123","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:06:56Z","timestamp":1787850416000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Cell competition driven by secreted ligands: Modeling liver metastasis of colorectal cancer"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-4155","authenticated-orcid":false,"given":"Hossein","family":"Nemati","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04pp8hn57","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Theoretical Physics, Department of Physics, Faculty of Science, Utrecht University, Princetonplein 5","place":["Utrecht, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-1307","authenticated-orcid":false,"given":"Saskia Jacoba Elisabeth","family":"Suijkerbuijk","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04pp8hn57","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8","place":["Utrecht, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-7368","authenticated-orcid":false,"given":"Joost","family":"de Graaf","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04pp8hn57","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Theoretical Physics, Department of Physics, Faculty of Science, Utrecht University, Princetonplein 5","place":["Utrecht, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00538-y"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-024-00530-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-0262-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.167486"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020107271"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109307"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03558-4"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03605-0"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03525-z"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10015-4"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84406-3"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/416755a"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.06.021"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02453"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.016"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(75)90330-9"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.076760"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(79)90284-7"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90261-X"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81512-3"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.05.002"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2024.06.022"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109718"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01268"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.049"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12389"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.06.012"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1199-y"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2021.02.012"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001140"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.1.1"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.09.009"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.061929"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","unstructured":"M. Amoyel B. D. Simons E. A. Bach Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. EMBO J. 33 2295\u20132313 (2014).","DOI":"10.15252\/embj.201387500"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1243148"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/embr.201337799"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21046"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2020.04.003"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.05.009"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2023.06.008"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-5809(70)90039-0"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-5809(90)90025-Q"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1086\/283633"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.09.110178.001201"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnsns.2022.106579"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.66.031102"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/4\/2\/005"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2017.09.019"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2016.07.028"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11538-019-00625-w"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-21822-9"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.2307\/j.ctvjghw98"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0305004100033193"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/16.2.97"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.27468"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00668"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03204"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-2789(86)90232-0"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2007.04.004"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12381"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/intbio\/zyae005"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005008"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521151113"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.74.061908"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevResearch.4.033156"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1140\/epje\/i2010-10677-0"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2015.0520"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1012993"},{"key":"e_1_3_4_69_2","doi-asserted-by":"crossref","unstructured":"D. Bi J. H. Lopez J. M. Schwarz M. L. Manning A density-independent rigidity transition in biological tissues. Nat. Phys. 11 1074\u20131079 (2015).","DOI":"10.1038\/nphys3471"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005569"},{"key":"e_1_3_4_71_2","first-page":"021011","article-title":"Motility-driven glass and jamming transitions in biological tissues","volume":"6","author":"Bi D.","year":"2016","unstructured":"D. Bi, X. Yang, M. C. Marchetti, M. L. Manning, Motility-driven glass and jamming transitions in biological tissues. Phys. Rev. X 6, 021011 (2016).","journal-title":"Phys. Rev. X"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1209\/0295-5075\/121\/36001"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8SM00126J"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.47.2128"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.2000.1087"},{"key":"e_1_3_4_76_2","doi-asserted-by":"crossref","unstructured":"S. E. M. Boas Y. Jiang R. M. H. Merks S. A. Prokopiou E. G. Rens \u201cCellular Potts model: Applications to vasculogenesis and angiogenesis\u201d in Probabilistic Cellular Automata: Theory Applications and Future Perspectives P. Y. Louis F. R. Nardi Eds. (Springer International Publishing Cham 2018) pp. 279\u2013310.","DOI":"10.1007\/978-3-319-65558-1_18"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00087"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4SM00445K"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1039\/D5SM00222B"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033501"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11831-019-09377-1"},{"key":"e_1_3_4_82_2","unstructured":"S. Monfared A. Arda\u0161eva A. Doostmohammadi Multi-phase-field models of biological tissues. arXiv [Preprint] (2025) https:\/\/arxiv.org\/abs\/2503.05053 (Accessed 2 October 2025)."},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-conmatphys-031218-013516"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.060640"},{"key":"e_1_3_4_85_2","doi-asserted-by":"crossref","unstructured":"L. C. Carpenter S. Banerjee Physical traits of supercompetitors in cell competition. bioRxiv [Preprint] (2024). https:\/\/biorxiv.org\/content\/10.1101\/2024.10.14.618306v1 (Accessed 2 October 2025).","DOI":"10.1101\/2024.10.14.618306"},{"key":"e_1_3_4_86_2","unstructured":"L. Br\u00e9zin K. S. Korolev Mechanically-driven growth and competition in a Voronoi model of tissues. arXiv [Preprint] (2024). https:\/\/arxiv.org\/abs\/2405.07899v1 (Accessed 2 October 2025)."},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-025-02150-9"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10867-024-09660-8"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61011"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2023.111666"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-020-03722-8"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3925-x"},{"key":"e_1_3_4_93_2","first-page":"1","article-title":"Liver metastases","volume":"7","author":"Tsilimigras D. I.","year":"2021","unstructured":"D. I. Tsilimigras , Liver metastases. Nat. Rev. Dis. Prim. 7, 1\u201323 (2021).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100997"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2024.103575"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.084111"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03493-3"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.032"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2005.apm_386.x"},{"key":"e_1_3_4_100_2","first-page":"389","article-title":"Transforming growth factor-alpha: An oncodevelopmental growth factor","volume":"2","author":"Salomon D. S.","year":"1990","unstructured":"D. S. Salomon, N. Kim, T. Saeki, F. Ciardiello, Transforming growth factor-alpha: An oncodevelopmental growth factor. Cancer Cells 2, 389\u2013397 (1990).","journal-title":"Cancer Cells"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28988"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i41.5148"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/35052073"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.3.11.1235"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910610425"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.1.2.108"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80076-2"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.4.1286"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2013.07.010"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.47.070178.003435"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10699"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(95)80067-0"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi057"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123327"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947601910392989"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000780"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06610.2002"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0160-9"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3246-04.2004"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2018.12.007"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185637"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110310"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2021.110998"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2007.07.002"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2025.0536"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp358"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2345"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.118.301507"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.12.2301"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.010488"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.07.007"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2435.13378"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.104.034416"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2006.04.020"},{"key":"e_1_3_4_135_2","unstructured":"H. Nemati Data from \u201cCell competition driven by secreted ligands: Modeling liver metastasis of colorectal cancer.\u201d Yoda. https:\/\/doi.org\/10.24416\/uu01-da6tug. Deposited 3 August 2026."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2531078123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:07:23Z","timestamp":1787850443000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2531078123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":135,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1073\/pnas.2531078123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2531078123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2531078123"}}