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Importantly, delivering IFN\u03b3 directly into tumors via convection-enhanced delivery enhances CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2013mediated killing of tumor cells and significantly prolongs survival in tumor-bearing mice. These studies highlight the importance of T cells in controlling brain tumors and the value of IFN\u03b3 as an adjuvant for T cell\u2013based immunotherapy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2531269123","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:05:01Z","timestamp":1789412701000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Local delivery of interferon restores antigen presentation and sensitizes medulloblastoma to T cell killing"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-6491","authenticated-orcid":false,"given":"Tanja","family":"Eisemann","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03m1g2s55","id-type":"ROR","asserted-by":"publisher"}],"name":"Cancer Genome and Epigenetics Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery 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