{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:02:50Z","timestamp":1791842570172,"version":"4.3.4"},"reference-count":117,"publisher":"National Academy of Sciences","issue":"26","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI166152"],"award-info":[{"award-number":["R21AI166152"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F30AI169967"],"award-info":[{"award-number":["F30AI169967"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>\n                    There is a constant tug-of-war for transition metals at the pathogen\u2013host interface. Vertebrate hosts modulate the availability of metals to pathogens in a process known as nutritional immunity, but pathogens have evolved numerous countermeasures to this host defense strategy. The bioavailability of trace metals therefore shapes the outcome of disease. In mammals, epithelial cells lining the intestine are a major site of metal absorption. Intestinal epithelial cells (IECs) are also a target for invading enteric pathogens but the contribution of epithelium-intrinsic factors toward nutritional immunity is unclear. Using\n                    <jats:italic toggle=\"yes\">\n                      <jats:italic toggle=\"yes\">Salmonella enterica<\/jats:italic>\n                    <\/jats:italic>\n                    serovar Typhimurium (STm) harboring genetically encoded fluorescent sensors for transition metals, we mapped the spatiotemporal nature of metal competition during enteric salmonellosis. In contrast to the metal replete lumen, a subpopulation of STm experience a temporal, cell-specific restriction of Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    (\u22640.1 \u00b5M), and possibly Mn\n                    <jats:sup>2+<\/jats:sup>\n                    , in both IECs and cells of the lamina propria during the early stages of infection. We further studied the contribution of the broad specificity divalent metal transporter, SLC11A2, in IECs to nutritional immunity against STm. SLC11A2 was recruited to maturing\n                    <jats:italic toggle=\"yes\">\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    <\/jats:italic>\n                    -containing vacuoles and knockout of\n                    <jats:italic toggle=\"yes\">SLC11A2<\/jats:italic>\n                    led to increased bacterial proliferation in IECs. Metal-responsive fluorescent reporters showed that vacuolar STm were less starved for Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , and possibly Mn\n                    <jats:sup>2+<\/jats:sup>\n                    , but not Zn\n                    <jats:sup>2+<\/jats:sup>\n                    or Mg\n                    <jats:sup>2+<\/jats:sup>\n                    in the absence of\n                    <jats:italic toggle=\"yes\">SLC11A2<\/jats:italic>\n                    . STm counters SLC11A2-mediated growth restriction in IECs via the Mn\n                    <jats:sup>2+<\/jats:sup>\n                    \/Fe\n                    <jats:sup>2+<\/jats:sup>\n                    transporter, MntH, and iron-binding siderophores. We conclude that SLC11A2-mediated sequestration of a subset of metals is an IEC innate defense mechanism against STm.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2532675123","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:02:29Z","timestamp":1782154949000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["SLC11A2 withholds divalent metals from\n                    <i>Salmonella<\/i>\n                    in the gut epithelium"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7540-9301","authenticated-orcid":false,"given":"Emilia S.","family":"Norberg","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0155zta11","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont","place":["Burlington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-1935","authenticated-orcid":false,"given":"Trina L.","family":"Westerman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01y2jtd41","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison","place":["Madison"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy","family":"Cruz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01y2jtd41","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison","place":["Madison"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5976-9805","authenticated-orcid":false,"given":"Summer D.","family":"Bushman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dq2gs74","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1988-7284","authenticated-orcid":false,"given":"John","family":"Salogiannis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0155zta11","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Physiology and Biophysics, Robert Larner, M.D. College of Medicine, University of Vermont","place":["Burlington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-8105","authenticated-orcid":false,"given":"Eric P.","family":"Skaar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dq2gs74","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-0713","authenticated-orcid":false,"given":"Johanna R.","family":"Elfenbein","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01y2jtd41","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison","place":["Madison"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-2198","authenticated-orcid":false,"given":"Leigh A.","family":"Knodler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0155zta11","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont","place":["Burlington"]},{"id":[{"id":"https:\/\/ror.org\/05dk0ce17","id-type":"ROR","asserted-by":"publisher"}],"name":"Paul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University","place":["Pullman"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240130021018"},{"key":"e_1_3_4_2_2","first-page":"96","volume-title":"The Nramp Family","author":"Canonne-Hergaux F.","year":"2004","unstructured":"F. Canonne-Hergaux, P. Gros, \u201cTissue distribution and subcellular localization of Nramp proteins\u201d in The Nramp Family (Kluwer Academic\/Plenum Publishers, 2004), pp. 96\u2013112."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020702213099"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1023"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0425"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/41343"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54705-0"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/248345a0"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/250353a0"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.127.6.2417"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.3.655"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1458"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.8.2923-2929.1996"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803053381002"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.733"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-019-06374-y"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.61.1.96"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.1.268"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01155.x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00412-13"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax7898"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.07.003"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01337.x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1111554"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-024-01613-0"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200732"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-383"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.1148"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003600050085"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-141-36720"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.13.3823"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.6.2157"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi048768"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24356"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2966"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1550"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4269"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2011.07.004"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2009.05.003"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16344"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12244"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01369-10"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01258.x"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111763"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2025.04.013"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2012.03.002"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.64.1081"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.10.956"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.9.575"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24033"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009280"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12086"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.01.017"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.005"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.06.007"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.6.1446-1453.1998"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.11.3610-3612.1999"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.12.3159-3166.2002"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01310-09"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-2-200"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.11.7161-7169.2005"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00874-13"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00143374"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9629(96)00403-3"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(95)80053-O"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.12.002"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.01.003"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2mt20024d"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126495"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.043588"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00479.2010"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606424103"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.5.3039"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.03.011"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.5.831"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001478200"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1182"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.12.006"},{"key":"e_1_3_4_79_2","doi-asserted-by":"crossref","unstructured":"R. Zhang Disruption of iron metabolism resulting from Dmt1\/Slc11A2 deficiency compromises notch protein degradation and transcriptional activation. FEBS J. (2026). 10.1111\/febs.70522.","DOI":"10.1111\/febs.70522"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030485"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006098107"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084681"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6581-6_19"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252415599"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-12-1096"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.1999.00003.x"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101334"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113925"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2839-2858.2003"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02863-14"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3483"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126789"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604636103"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003456"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27297-2"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2016.10.004"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3MT00352C"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00559-07"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.111.3.731-738.1972"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01320.x"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.06089.x"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1039\/d0mt00178c"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07357.x"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01783.x"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1913991116"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan6361"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.02.035"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.09.034"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.06.023"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16946"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.12.009"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.78.21.706"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.07.002"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099820"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(95)00193-A"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.032896-0"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90366-J"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2532675123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:05:44Z","timestamp":1782155144000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2532675123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":117,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2026,6,30]]}},"alternative-id":["10.1073\/pnas.2532675123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2532675123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"2025-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2532675123"}}