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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:p>\n                    Mutualistic symbioses are potentially vulnerable to exploitation, particularly in hosts that acquire symbionts from the environment, where harmful exploiters inhabit. The independent evolution and persistence of intricate partner-choice mechanisms in many symbioses testify the threat by specialized exploiters of mutualisms, although only few have been documented in nature. We report here a lethal \u201cTrojan horse\u201d pathogen,\n                    <jats:italic toggle=\"yes\">Burkholderia<\/jats:italic>\n                    sp. SJ1, exploiting the stinkbug\u2013\n                    <jats:italic toggle=\"yes\">Caballeronia<\/jats:italic>\n                    gut symbiosis. This bacterium resembles symbionts by using wrapping motility to traverse the host\u2019s sorting organ, inducing symbiotic organ morphogenesis and colonizing it. Unlike mutualists, however, it resists host digestion for nutrient acquisition, breaches the gut epithelium, and causes sepsis, rapidly killing the host. Colonization of the symbiotic organ is essential for its lethality. This case shows how pathogens can exploit mutualisms, highlighting the evolutionary pressures shaping partner-choice mechanisms and the fragility of even highly specialized mutualisms.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2533244123","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:59:57Z","timestamp":1777399197000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["A Trojan horse pathogen breaking through partner-choice barriers in the insect gut"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-5858","authenticated-orcid":false,"given":"Kota","family":"Ishigami","sequence":"first","affiliation":[{"name":"Faculty of Agriculture, University of the Ryukyus","place":["Nishihara, Okinawa, Japan"]},{"name":"Unit of Applied Biological Chemistry, Graduate School of Agriculture, Hokkaido University","place":["Sapporo, 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France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-6912","authenticated-orcid":false,"given":"Lionel","family":"Moulin","sequence":"additional","affiliation":[{"name":"Plant Health Institute of Montpellier (PHIM), IRD, CIRAD, INRAE, Institut Agro, Univ Montpellier","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine-Olivier","family":"Lirette","sequence":"additional","affiliation":[{"name":"Unit of Applied Biological Chemistry, Graduate School of Agriculture, Hokkaido University","place":["Sapporo, Japan"]},{"name":"Biomanufacturing Process Research Center, National Institute of Advanced Industrial Science and Technology, Hokkaido Center","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Faculty of Bioresource Sciences, Akita Prefectural 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Ishigami Raw data for \u201cA Trojan horse pathogen breaking through partner-choice barriers in the insect gut.\u201d Figshare. https:\/\/doi.org\/10.6084\/m9.figshare.31338493. Deposited 14 February 2026."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2533244123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:02:11Z","timestamp":1777399331000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2533244123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":67,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,5,5]]}},"alternative-id":["10.1073\/pnas.2533244123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2533244123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2533244123"}}