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Furthermore, TBK1 activation correlates with enhanced p53 signaling and genomic instability, providing a molecular basis for its pro-death effects under chemotherapy. Collectively, these findings reveal a previously unrecognized function of TBK1 in modulating the DNA-damage response, linking inflammatory signaling to genome destabilization and identifying the TBK1\u2013MRE11 axis as a potential target to enhance chemotherapeutic efficacy.<\/jats:p>","DOI":"10.1073\/pnas.2533402123","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:25:05Z","timestamp":1786724705000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory kinase TBK1 suppresses homologous recombination DNA repair to sensitize tumors to chemotherapy"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-1922","authenticated-orcid":false,"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01yqg2h08","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Life Science and Technology, Harbin 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