{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:57:03Z","timestamp":1792173423697,"version":"4.4.0"},"reference-count":135,"publisher":"National Academy of Sciences","issue":"42","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["341268"],"award-info":[{"award-number":["341268"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["180414"],"award-info":[{"award-number":["180414"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["358654"],"award-info":[{"award-number":["358654"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["148425"],"award-info":[{"award-number":["148425"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["191775"],"award-info":[{"award-number":["191775"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:p>The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades, yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association between an elevated paternal Body Mass Index (BMI) and age as factors implicated in increased risk for neurodevelopmental disorders in children. Epigenetic regulation of gene expression by DNA methylation at cytosines is susceptible to environmental, diet, and lifestyle changes. Yet, whether a man\u2019s BMI and age influence the sperm methylome and potentially impact offspring development remains unresolved. Using MethylC capture sequencing, we identified over 38,000 differentially methylated CpGs in the sperm of men with an elevated BMI, with overlap occurring in regions associated with advanced paternal age. These were enriched for neural gene and disease ontologies. Differentially methylated regions localized to transposable elements that can act as active enhancers during human zygotic genome activation, and at gene promoters for early lineage specification. These results suggest that sperm methylome alterations that are linked to an elevated BMI may influence key embryonic transcriptional processes, notably those associated with trophectoderm and placental development.<\/jats:p>","DOI":"10.1073\/pnas.2534171123","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:39:04Z","timestamp":1792172344000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0373-4264","authenticated-orcid":false,"given":"Mathieu","family":"Schulz","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Cell Biology, University of Montreal Hospital Research Center","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-621X","authenticated-orcid":false,"given":"Xiaojian","family":"Shao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mte1k06","id-type":"ROR","asserted-by":"publisher"}],"name":"Digital Technologies Research Center, National Research Council of Canada","place":["Ottawa, Canada"]},{"id":[{"id":"https:\/\/ror.org\/03c4mmv16","id-type":"ROR","asserted-by":"publisher"}],"name":"Ottawa Institute of Systems Biology, Department of Biochemistry Microbiology and Immunology, University of Ottawa","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Lambrot","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Cell Biology, University of Montreal Hospital Research Center","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lafleur","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Cell Biology, University of Montreal Hospital Research Center","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donovan","family":"Chan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04pemf943","id-type":"ROR","asserted-by":"publisher"}],"name":"Child Health and Human Development Program, Research Institute of the McGill University Health Centre","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7009-9104","authenticated-orcid":false,"given":"Marie-Charlotte","family":"Dumargne","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/035b05819","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Basic Metabolic Research, University of Copenhagen","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-3483","authenticated-orcid":false,"given":"Amanda J.","family":"MacFarlane","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05p8nb362","id-type":"ROR","asserted-by":"publisher"}],"name":"Nutrition Research Division, Health Canada","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Moskovtsev","sequence":"additional","affiliation":[{"name":"CReATe Fertility Clinic Center","place":["Toronto, Canada"]},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-9656","authenticated-orcid":false,"given":"Guillaume","family":"Bourque","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"McGill Genome Center, Department of Human Genetics, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi","family":"Pastinen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"McGill Genome Center, Department of Human Genetics, McGill University","place":["Montreal, Canada"]},{"id":[{"id":"https:\/\/ror.org\/04zfmcq84","id-type":"ROR","asserted-by":"publisher"}],"name":"Genomic medicine Center, Children\u2019s Mercy Hospital","place":["Kansas City"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Librach","sequence":"additional","affiliation":[{"name":"CReATe Fertility Clinic Center","place":["Toronto, Canada"]},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Obstetrics and Gynecology, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope","family":"Weiler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05p8nb362","id-type":"ROR","asserted-by":"publisher"}],"name":"Nutrition Research Division, Bureau of Nutritional Sciences, Food and Nutrition Directorate, Health Products and Food Branch, Health Canada","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquetta","family":"Trasler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04pemf943","id-type":"ROR","asserted-by":"publisher"}],"name":"Child Health and Human Development Program, Research Institute of the McGill University Health Centre","place":["Montreal, Canada"]},{"id":[{"id":"https:\/\/ror.org\/04pemf943","id-type":"ROR","asserted-by":"publisher"}],"name":"Departments of Pediatrics, Human Genetics, Pharmacology and Therapeutics, Research Institute of the McGill University Health Centre, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-7233","authenticated-orcid":false,"given":"Sarah","family":"Kimmins","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Cell Biology, University of Montreal Hospital Research Center","place":["Montreal, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology and Therapeutics, McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1089"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.08.014"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/311374a0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/308548a0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5143"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23596-w"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.001"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8466"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2005.04.009"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.158"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv028"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10050274"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7202a1"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3664"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.05.022"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12666"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02046-7"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP4812"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP12013"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117941"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.01.014"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.06.001"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13544"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10168"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009846"},{"key":"e_1_3_4_26_2","first-page":"1","article-title":"Hominoid-specific transposable elements and KZFPs facilitate human embryonic genome activation and control transcription in naive human ESCs","volume":"24","author":"Pontis J.","year":"2019","unstructured":"J. Pontis, T. W. Theunissen, R. Jaenisch, T. Correspondence, Hominoid-specific transposable elements and KZFPs facilitate human embryonic genome activation and control transcription in naive human ESCs. Stem Cell 24, 1\u201312 (2019).","journal-title":"Stem Cell"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0347"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv338"},{"key":"e_1_3_4_29_2","volume-title":"Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction","author":"WHO","year":"1999","unstructured":"WHO, Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction (Cambridge University Press, Cambridge, New York, NY, 1999)."},{"key":"e_1_3_4_30_2","unstructured":"World Health Organization Obesity and overweight. (2024). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa407"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.17-0196"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00988-1"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giz037"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr167"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_4_38_2","volume-title":"Picard Toolkit","author":"Broad Institute","year":"2019","unstructured":"Broad Institute, Picard Toolkit (Broad Institute, 2019)."},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45839-z"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-7-r61"},{"key":"e_1_3_4_41_2","unstructured":"J. D. Storey A. J. Bass A. Dabney D. Robinson Q-value estimation for false discovery rate control. R package version 2.38.0. https:\/\/github.com\/jdstorey\/qvalue (2024)."},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109418"},{"key":"e_1_3_4_44_2","first-page":"1581","article-title":"Sperm epigenetic clock associates with pregnancy outcomes in the general population","volume":"37","author":"Pilsner J. R.","year":"2022","unstructured":"J. R. Pilsner , Sperm epigenetic clock associates with pregnancy outcomes in the general population. Hum. Reprod. 37, 1581\u20131593 (2022).","journal-title":"Hum. Reprod."},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278663"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0080-8"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.06.006"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1113"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac102"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01232-7"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2024.04.017"},{"key":"e_1_3_4_53_2","unstructured":"G. Czanner S. V. Sarma U. T. Eden E. N. Brown A signal-to-noise ratio estimator for generalized linear model systems. Lect. Notes Eng. Comput. Sci. 2171 1063\u20131069 (2008)."},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006957"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02058-x"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32781"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0166-0"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.11.004"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276469"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2599"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08162"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34800-w"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.168872.113"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01789-5"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0004-3"},{"key":"e_1_3_4_66_2","article-title":"Obesity: A chronic low-grade inflammation and its markers","volume":"14","author":"Khanna D.","year":"2022","unstructured":"D. Khanna, S. Khanna, P. Khanna, P. Kahar, B. M. Patel, Obesity: A chronic low-grade inflammation and its markers. Cureus 14, e22711 (2022).","journal-title":"Cureus"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology3020403"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-009-9346-2"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05841-x"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36364-9"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0479-7"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101427"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1999-0"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05780-11"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93885-3"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8914"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.196139.115"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.826665"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3179"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.09.158"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqad066"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.188763"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq064"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-023-01199-x"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09972"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0018"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12591"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.12.008"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200859"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201538"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab2006"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00997-0"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01117"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2020.05.009"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29792-6"},{"key":"e_1_3_4_96_2","first-page":"52","article-title":"New nucleophilic mechanisms of ros-dependent epigenetic modifications: Comparison of aging and cancer","volume":"5","author":"Afanas\u2019ev I.","year":"2013","unstructured":"I. Afanas\u2019ev, New nucleophilic mechanisms of ros-dependent epigenetic modifications: Comparison of aging and cancer. Aging Dis. 5, 52\u201362 (2013).","journal-title":"Aging Dis."},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501034102"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.09.012"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25544-0"},{"key":"e_1_3_4_100_2","first-page":"1257","article-title":"Age-related methylation changes in the human sperm epigenome","volume":"15","author":"Bernhardt L.","year":"2023","unstructured":"L. Bernhardt , Age-related methylation changes in the human sperm epigenome. Aging 15, 1257\u20131278 (2023).","journal-title":"Aging"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83288"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101463"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.08.024"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.01.028"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07472-3"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07963-3"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50930-9"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.29"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80857-2"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-023-01162-w"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57760-3"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80209-9"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00001.2023"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01521-7"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2534-15.2016"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.119"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07336-w"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001214"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.043"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65641"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.07.010"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1216154"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.032"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.320069.118"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3718"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-024-01405-4"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw5118"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.323105.118"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13662-9"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2214988119"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.04.014"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.047"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-023-00820-4"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1111\/andr.70131"},{"key":"e_1_3_4_135_2","doi-asserted-by":"crossref","unstructured":"M. Schulz A functional genomic links differential sperm methylation from overweight men to transposable element regulation in paternal origins of disease risk in children. European Genome-phenome Archive. https:\/\/www.ega-archive.org\/studies\/EGAS50000001028. Deposited 15 June 2025.","DOI":"10.1101\/2025.09.15.675616"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2534171123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:39:51Z","timestamp":1792172391000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2534171123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":135,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2026,10,20]]}},"alternative-id":["10.1073\/pnas.2534171123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2534171123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"2025-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2534171123"}}