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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:p>\n                    Plants survive extreme environments through rapid chromatin reprogramming, yet the epigenetic marks that confer stress resilience remain poorly understood. Histone deacetylase HDA19 is a key epigenetic regulator in Arabidopsis, and\n                    <jats:italic toggle=\"yes\">hda19<\/jats:italic>\n                    -deficient mutants display tolerance to multiple abiotic stresses, including drought, heat, and salinity. Using lysine acetylome profiling, we identified a noncanonical K27\/K36 diacetylation mark on histone H3.3, among nine H3 variants, as a specific substrate of HDA19. Under salinity stress, this mark decreased in wild-type plants but increased in\n                    <jats:italic toggle=\"yes\">hda19<\/jats:italic>\n                    mutants, while other known H3 modifications were similarly affected in both genotypes. Mimicking constitutive diacetylation of H3.3K27\/K36 through lysine-to-glutamine substitutions promoted accumulation of stress-responsive late embryogenesis abundant (LEA) proteins and conferred salinity tolerance in seedlings, phenocopying\n                    <jats:italic toggle=\"yes\">hda19<\/jats:italic>\n                    mutants. Furthermore, generating the\n                    <jats:italic toggle=\"yes\">lea7-1\/lea29-1\/rab18-1<\/jats:italic>\n                    triple mutant abolished\n                    <jats:italic toggle=\"yes\">hda19<\/jats:italic>\n                    -dependent salinity tolerance, confirming the LEA proteins\u2019 role downstream of HDA19. Our findings demonstrate that H3.3K27\/K36 diacetylation, modulated by HDA19, drives LEA protein accumulation and enables plants to withstand environmental stress, revealing a core mechanism of plant stress resilience.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2534315123","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:01:17Z","timestamp":1783969277000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["HDA19-mediated deacetylation of histone H3.3 at lysines 27 and 36 regulates plant sensitivity to salt stress"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2640-2761","authenticated-orcid":false,"given":"Florian","family":"Kotnik","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00pd74e08","id-type":"ROR","asserted-by":"publisher"}],"name":"Plant Physiology, Institute of Plant Biology and Biotechnology, University 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