{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:29:39Z","timestamp":1789655379705,"version":"4.0.1"},"reference-count":99,"publisher":"National Academy of Sciences","issue":"20","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-185834"],"award-info":[{"award-number":["PJT-185834"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2022-03918"],"award-info":[{"award-number":["RGPIN-2022-03918"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPiN-2024-04335"],"award-info":[{"award-number":["RGPiN-2024-04335"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-169174"],"award-info":[{"award-number":["PJT-169174"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR082973"],"award-info":[{"award-number":["R01AR082973"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"publisher","award":["707634"],"award-info":[{"award-number":["707634"]}],"id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG063534"],"award-info":[{"award-number":["R21AG063534"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR004409"],"award-info":[{"award-number":["UM1TR004409"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA042014"],"award-info":[{"award-number":["P30CA042014"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR084430"],"award-info":[{"award-number":["R01AR084430"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:p>\n                    Erosive hand osteoarthritis (EHOA) is a chronic joint disease characterized by severe inflammation and degeneration of cartilage and bone tissue. As this disease is multifactorial in nature, the molecular mechanisms that influence its pathogenesis are unclear, leading to a lack of disease-modifying therapies. However, by screening 40 families with a dominant inheritance pattern for EHOA, we identified two independent germline heterozygous mutations that associated with EHOA onset:\n                    <jats:italic toggle=\"yes\">PANX1<\/jats:italic>\n                    [c.G455A:p.R152H] and\n                    <jats:italic toggle=\"yes\">PANX3<\/jats:italic>\n                    [c.G71A:p.R24H]. Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are mechanosensitive channel-forming glycoproteins that pass various metabolites and ions such as adenosine triphosphate (ATP) and calcium to regulate numerous physiological and cellular processes including tissue development, cell differentiation, and homeostasis. In this study, we report that electrophysiological recordings, ATP release, and basal dye uptake assays revealed increased channel activity of the PANX1 R152H variant, which led to increased cytotoxicity following long-term expression. In contrast, R24H mutant PANX3 channels exhibited a loss-of-function in mechanically stimulated dye uptake assays. Under stable, moderate expression conditions, this reduction in channel activity was associated with decreased cell growth, whereas overexpression led to increased cell death. In vivo, R24H expression in zebrafish embryos increased apoptosis and upregulation of\n                    <jats:italic toggle=\"yes\">p21<\/jats:italic>\n                    and osteogenic genes. Together these findings demonstrate that two mutations with opposing alterations in PANX channel activity, hyperactivity in R152H PANX1 and loss-of-function in R24H PANX3, can converge on degenerative cellular outcomes. Collectively, we report the first germline PANX3 mutation associated with disease and provide the first evidence linking PANX1 and PANX3 mutations to human erosive osteoarthritis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2535302123","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:39:43Z","timestamp":1778693983000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["Human pannexin mutations and their implications in erosive osteoarthritis"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9942-6655","authenticated-orcid":false,"given":"Justin","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario","place":["London, Canada"]},{"name":"Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7892-6820","authenticated-orcid":false,"given":"Jason","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario","place":["London, Canada"]},{"name":"Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-3872","authenticated-orcid":false,"given":"Kazuyuki","family":"Hoshijima","sequence":"additional","affiliation":[{"name":"Department of Orthopedics School of Medicine, University of Utah","place":["Salt Lake City"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Wakefield","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario","place":["London, Canada"]},{"name":"Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1112-6947","authenticated-orcid":false,"given":"Donglin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0536-6656","authenticated-orcid":false,"given":"Peter B.","family":"Stathopulos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7019-7246","authenticated-orcid":false,"given":"Roger J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander W.","family":"Lohman","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-9164","authenticated-orcid":false,"given":"Michael J.","family":"Jurynec","sequence":"additional","affiliation":[{"name":"Department of Orthopedics School of Medicine, University of Utah","place":["Salt Lake City"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8505-7537","authenticated-orcid":false,"given":"Frank","family":"Beier","sequence":"additional","affiliation":[{"name":"Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital","place":["London, Canada"]},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-5517","authenticated-orcid":false,"given":"Silvia","family":"Penuela","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario","place":["London, Canada"]},{"name":"Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_3_4_1_2","unstructured":"Government of Canada Osteoarthritis in Canada (P. H. A. Canada 2020)."},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1369-7"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(05)80009-5"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780090302"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21658"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2004.05.010"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.33502"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133017"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143016"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.08.004"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213826"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-023-01130-9"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.016881"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-015-0528-x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.6.470"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2010.507216"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(03)00054-2"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41520"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2025-005707"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.01.017"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702422200"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201101050"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0150"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.009514"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516678203"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.509"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-021-09805-7"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50444-1"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.323378"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2740"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09413"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100478"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13147"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3954"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13914"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9384"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.621219"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1159\/000486023"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.523241"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55371-9"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.127027"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177557"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1311-1"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41651"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25830"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/jbmrpl\/ziaf057"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S128401"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601378"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.004804"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.10.006"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-021-09804-8"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1160583"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002780"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8965"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12988"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.717934"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav8731"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-00807-4"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-10-0585"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201511505"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-01-0067"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1080\/15419060802014115"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39512"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165209"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2679"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2022.08.004"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2022-222497"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.43164"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2023.101698"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.176883"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.056093"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031080"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0021"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506415200"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90499-G"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.10.097"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1102703"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1270"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401373"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.01.009"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12869"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03083"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00344-7"},{"key":"e_1_3_4_84_2","first-page":"468","article-title":"Erosive osteoarthritis","volume":"9","author":"Anandarajah A.","year":"2010","unstructured":"A. Anandarajah, Erosive osteoarthritis. Discov. Med. 9, 468\u2013477 (2010).","journal-title":"Discov. Med."},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-01037-4"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0334-8"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy196"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0892-0_14"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0310-0"},{"key":"e_1_3_4_90_2","doi-asserted-by":"crossref","unstructured":"Z. Hang Z. Huawei W. Daping Cryo-EM structure of human pannexin3. RCSB PDB. https:\/\/www.rcsb.org\/structure\/7XL6. Accessed 11 July 2024.","DOI":"10.2210\/pdb8wza\/pdb"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000440"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3280"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11010102"},{"key":"e_1_3_4_95_2","first-page":"1","volume-title":"The Zebrafish Book: A Guide for the Laboratory use of Zebrafish Danio (Brachydanio) Rerio","author":"Westerfield M.","year":"2000","unstructured":"M. Westerfield, The Zebrafish Book: A Guide for the Laboratory use of Zebrafish Danio (Brachydanio) Rerio (ZFIN, Eugene, OR, ed. 4th, 2000), pp. 1.","edition":"4"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198809010-00017"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2016.04.008"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002861"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.180133"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2535302123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:39:58Z","timestamp":1778693998000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2535302123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":99,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,5,19]]}},"alternative-id":["10.1073\/pnas.2535302123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2535302123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2535302123"}}