{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:51:11Z","timestamp":1791312671505,"version":"4.3.1"},"reference-count":53,"publisher":"National Academy of Sciences","issue":"41","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016063","name":"Stichting Steunfonds Uitzicht","doi-asserted-by":"publisher","award":["2023-07"],"award-info":[{"award-number":["2023-07"]}],"id":[{"id":"10.13039\/100016063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["91120067"],"award-info":[{"award-number":["91120067"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INTENSE LSH-NWO","award":["TTW\/00798883"],"award-info":[{"award-number":["TTW\/00798883"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:p>\n                    Infantile nystagmus is a debilitating involuntary eye movement disorder often associated with retinal diseases such as congenital stationary night blindness (CSNB). The oscillating eye movements of infantile nystagmus come with reduced visual acuity and strongly impair quality of life. No cure exists for this condition. Previously, we demonstrated that nystagmus in the CSNB mouse model\n                    <jats:italic toggle=\"yes\">\n                      Nyx\n                      <jats:sup>nob<\/jats:sup>\n                    <\/jats:italic>\n                    has a retinal cause. Specifically, we found that synchronized oscillations of retinal ganglion cells (RGCs) are transmitted to the accessory optic system, triggering compensatory eye movements. The RGC oscillations appear to originate from a specific retinal cell type, the A\n                    <jats:sub>II<\/jats:sub>\n                    amacrine cell (A\n                    <jats:sub>II<\/jats:sub>\n                    AC), making these cells the preferred target for treatment. The reason for the oscillations in the A\n                    <jats:sub>II<\/jats:sub>\n                    ACs is not fully understood. Here, we found that pharmacologically activating the D1 dopaminergic receptors on the A\n                    <jats:sub>II<\/jats:sub>\n                    ACs in\n                    <jats:italic toggle=\"yes\">\n                      Nyx\n                      <jats:sup>nob<\/jats:sup>\n                    <\/jats:italic>\n                    mice down-regulated their voltage-gated sodium and potassium channels, leading to a complete suppression of the pathological oscillations of both A\n                    <jats:sub>II<\/jats:sub>\n                    ACs and RGCs. Furthermore, the signal fidelity of RGCs significantly improved due to the absence of the pathological oscillations. Our retinal network simulations confirm that the experimentally observed changes in properties of the A\n                    <jats:sub>II<\/jats:sub>\n                    AC voltage-gated currents are necessary and sufficient to account for the dopamine-dependent abolishment of these oscillations. Our findings provide a mechanistic understanding of dopaminergic regulation of A\n                    <jats:sub>II<\/jats:sub>\n                    ACs underlying infantile nystagmus.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2535572123","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:38Z","timestamp":1791309878000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Dopamine suppresses pathological retinal oscillations and enhances the signal-to-noise ratio"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-3605","authenticated-orcid":false,"given":"B. Semihcan","family":"Sermet","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043c0p156","id-type":"ROR","asserted-by":"publisher"}],"name":"Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4194-7440","authenticated-orcid":false,"given":"Wouter","family":"Kamermans","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043c0p156","id-type":"ROR","asserted-by":"publisher"}],"name":"Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beerend H. J.","family":"Winkelman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043c0p156","id-type":"ROR","asserted-by":"publisher"}],"name":"Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences","place":["Amsterdam, The Netherlands"]},{"id":[{"id":"https:\/\/ror.org\/018906e22","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, Erasmus University Medical Center","place":["Rotterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-8187","authenticated-orcid":false,"given":"Chris I.","family":"De Zeeuw","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043c0p156","id-type":"ROR","asserted-by":"publisher"}],"name":"Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences","place":["Amsterdam, The Netherlands"]},{"id":[{"id":"https:\/\/ror.org\/018906e22","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, Erasmus University Medical Center","place":["Rotterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-828X","authenticated-orcid":false,"given":"Maarten","family":"Kamermans","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043c0p156","id-type":"ROR","asserted-by":"publisher"}],"name":"Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X00081991"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)31131-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14756"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13455"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7760"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11992"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/09273970903396893"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12293"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/81619"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00608.2007"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP284965"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fopht.2023.1186280"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000174"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.032"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00104"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S095252380000941X"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3096-04.2004"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0736-25.2025"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2011.12.006"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086253"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00437.2014"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2019.03.006"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337681100"},{"key":"e_1_3_4_24_2","first-page":"355","article-title":"Exploring the retinal connectome","volume":"17","author":"Anderson J. R.","year":"2011","unstructured":"J. R. Anderson , Exploring the retinal connectome. Mol. Vis. 17, 355\u2013379 (2011).","journal-title":"Mol. Vis."},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13144"},{"key":"e_1_3_4_26_2","unstructured":"P. S. Junior C. M. Wakeham H. von Gersdorff Dopamine regulates the membrane potential and glycine release of AII amacrine cells via D1-like receptor modulation of gap junction coupling. [Preprint] bioRxiv (2024). https:\/\/www.biorxiv.org\/content\/10.1101\/2024.12.11.625486v1 [Accessed 23 October 2025]."},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109091"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0643"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.39866"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.01.042"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4212-09.2010"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S095252389916512X"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07330.1997"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3827-09.2009"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.03.002"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.033"},{"key":"e_1_3_4_37_2","first-page":"346","article-title":"Congenital see-saw nystagmus associated with retinitis pigmentosa","volume":"18","author":"Bergin D. J.","year":"1986","unstructured":"D. J. Bergin, J. Halpern, Congenital see-saw nystagmus associated with retinitis pigmentosa. Ann. Ophthalmol. 18, 346\u2013349 (1986).","journal-title":"Ann. Ophthalmol."},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcad052"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/vision9010007"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44373-3"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.18034"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62734-0"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910789"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101830"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adq6320"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12058"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2013.807931"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.110014"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1159\/000323179"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063202"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1810-19.2020"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(96)00179-4"},{"key":"e_1_3_4_53_2","unstructured":"B. S. Sermet W. Kamermans B. H. J. Winkelman C. I. De Zeeuw M. Kamermans Dataset for \u201cDopamine suppresses pathological retinal oscillations and enhances the signal-to-noise ratio\u201d. Zenodo. https:\/\/doi.org\/10.5281\/zenodo.22830468. Deposited 18 September 2026."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2535572123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:05:37Z","timestamp":1791309937000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2535572123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":53,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,10,13]]}},"alternative-id":["10.1073\/pnas.2535572123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2535572123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2025-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2535572123"}}