{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:39:44Z","timestamp":1785436784920,"version":"3.56.0"},"reference-count":87,"publisher":"National Academy of Sciences","issue":"27","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1163335"],"award-info":[{"award-number":["1163335"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2019024"],"award-info":[{"award-number":["2019024"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. 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Mice with a B cell\u2013specific deletion of\n                    <jats:italic toggle=\"yes\">Cxcr3<\/jats:italic>\n                    displayed a 50 to 60% reduction in the frequency and number of ectopic GCB cells in the lungs at the peak of the response following IAV infection, relative to controls. Furthermore, in cotransfers,\n                    <jats:italic toggle=\"yes\">Cxcr3<\/jats:italic>\n                    -deficient B cells were substantially outcompeted by their\n                    <jats:italic toggle=\"yes\">Cxcr3<\/jats:italic>\n                    -sufficient counterparts for ectopic pulmonary GC participation, but were not impacted with respect to GCB cell frequencies in other compartments. Thus, the data elucidate the requirement of B cell\u2013intrinsic CXCR3 expression for efficient generation of ectopic pulmonary GCB cell responses in iBALT following respiratory viral infection with IAV, a finding that broadens understanding of the molecular cues underpinning this key component of local protective humoral immunity to IAV.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2535787123","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:43:55Z","timestamp":1782841435000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["B cell\u2013intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4729-6390","authenticated-orcid":false,"given":"Timona 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