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In paralyzed mice significant damage was observed in the outer layers of the cerebrum, and numerous condensed neuronal nuclei were present. In contrast, intracerebral inoculation of adolescent (3- to 4-week-old) transgenic mice with echovirus type 1 did not lead to paralysis but an acute wasting phenotype and myocarditis. These findings establish human very late antigen 2 transgenic mice as a model for echovirus pathogenesis.<\/jats:p>","DOI":"10.1073\/pnas.2535934100","type":"journal-article","created":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T12:58:11Z","timestamp":1072184291000},"page":"15906-15911","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":28,"title":["Transgenic mouse model for echovirus myocarditis and paralysis"],"prefix":"10.1073","volume":"100","author":[{"given":"Scott A.","family":"Hughes","sequence":"first","affiliation":[{"name":"Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshwardhan M.","family":"Thaker","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent R.","family":"Racaniello","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,12,12]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.2.346"},{"key":"e_1_3_2_2_2","first-page":"114","volume":"24","year":"1978","unstructured":"Grist, N. 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