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Both exhibit specific binding to human GPR84-expressing cells, with [\n                    <jats:sup>18<\/jats:sup>\n                    F]MGX-110S demonstrating superior affinity, selectivity, and signal-to-background ratio. [\n                    <jats:sup>18<\/jats:sup>\n                    F]MGX-110S enables sensitive detection of systemic- and neuro-inflammation in LPS-treated mice and outperforms PET images obtained using a radiotracer specific for translocator protein 18 kDa in 5xFAD mice\u2014revealing pathology-correlated activation across cortical, hippocampal, and thalamic regions. Taken together, our data indicate that [\n                    <jats:sup>18<\/jats:sup>\n                    F]MGX-110S is a highly sensitive and specific tool for visualizing maladaptive myeloid cell activation; its clinical translation could enable more precise detection and staging of inflammation in addition to improved therapeutic monitoring in neurodegenerative disorders and more broadly in inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2536372123","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:58:50Z","timestamp":1779379130000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":4,"title":["Illuminating proinflammatory myeloid cells with PET tracers targeting 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