{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:57:09Z","timestamp":1785859029822,"version":"3.56.0"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"31","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR36631\/BRB\/10\/ 1862\/2020"],"award-info":[{"award-number":["BT\/PR36631\/BRB\/10\/ 1862\/2020"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BRIC NII","award":["Core"],"award-info":[{"award-number":["Core"]}]},{"name":"Department of Science and Technology, India","award":["DST-INSPIRE"],"award-info":[{"award-number":["DST-INSPIRE"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:p>\n                    While preserving tolerance toward commensals, dendritic cells (DCs) also orchestrate response against pathogens. The noncanonical RelB NF-\u03baB pathway in DCs curbs tolerogenic Tregs in the intestine. Whether RelB-dependent DC regulations also impact intestinal immunity remains less clear. Here, we show that genetic ablation of RelB in DCs compromises IL-23-dependent immune response in the intestine, imparting vulnerability in\n                    <jats:italic toggle=\"yes\">\n                      Relb\n                      <jats:sup>\u0394CD11c<\/jats:sup>\n                    <\/jats:italic>\n                    mice to infection with\n                    <jats:italic toggle=\"yes\">\n                      <jats:italic toggle=\"yes\">Citrobacter<\/jats:italic>\n                      rodentium\n                    <\/jats:italic>\n                    , an enteropathogen. Our mechanistic studies revealed that RelB supported the expression of RBP-J from a \u03baB site-driven promoter, tuning Notch2 response in DCs. This RelB-mediated Notch2 control specified a solitary isolated lymphoid tissue\u2013resident DC subset, which served as a dominant source of IL-23 in infected mice. Indeed, we found that IL-23 supplementation readily rescued the immune deficiency of\n                    <jats:italic toggle=\"yes\">\n                      Relb\n                      <jats:sup>\u0394CD11c<\/jats:sup>\n                    <\/jats:italic>\n                    mice, improving bacterial clearance. In sum, we illustrate a previously unrecognized crosstalk between RelB and Notch2 underpinning IL-23-secreting DCs critical for gut immunity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2600771123","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:28:06Z","timestamp":1785342486000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["RelB NF-\u03baB tunes Notch2 signaling to promote IL-23-secreting solitary isolated lymphoid tissue\u2013resident DCs critical for gut immunity"],"prefix":"10.1073","volume":"123","author":[{"given":"Naveen","family":"Kumar","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fhee747","id-type":"ROR","asserted-by":"publisher"}],"name":"Systems Immunology Laboratory, Biotechnology Research and Innovation Council-National Institute of Immunology","place":["New Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvina","family":"Deka","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fhee747","id-type":"ROR","asserted-by":"publisher"}],"name":"Systems Immunology Laboratory, Biotechnology Research and Innovation Council-National Institute of Immunology","place":["New Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2951-2194","authenticated-orcid":false,"given":"Swapnava","family":"Basu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fhee747","id-type":"ROR","asserted-by":"publisher"}],"name":"Systems Immunology Laboratory, Biotechnology Research and Innovation Council-National Institute of Immunology","place":["New Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish 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