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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,27]]},"abstract":"<jats:p>\n                    Synaptic remodeling in emotional circuits contributes to the development of stress-related emotional disorders. However, such remodeling generally exhibits considerable heterogeneity across specific neuronal populations and the underlying molecular mechanisms remain poorly understood. Here, we identified\n                    <jats:italic toggle=\"yes\">C1ql2<\/jats:italic>\n                    as a key molecular regulator that governs projection-specific synaptic vulnerability within basolateral amygdala (BLA). Transcriptional profiling revealed that\n                    <jats:italic toggle=\"yes\">C1ql2<\/jats:italic>\n                    expression is enriched in BLA neurons projecting to ventral hippocampus (BLA\n                    <jats:sup>\u2192vHPC<\/jats:sup>\n                    PNs), but not in those projecting to nucleus accumbens (NAc), and is significantly down-regulated following chronic social defeat stress (CSDS). Gain- and loss-of-function manipulations demonstrated that\n                    <jats:italic toggle=\"yes\">C1ql2<\/jats:italic>\n                    regulates stress-induced neuronal remodeling in BLA\n                    <jats:sup>\u2192vHPC<\/jats:sup>\n                    PNs, including dendritic hypertrophy, synaptic outgrowth, and enhanced glutamatergic transmission, thereby shaping susceptibility to anxiety-like behavior. We further found that CSDS-induced\n                    <jats:italic toggle=\"yes\">C1ql2<\/jats:italic>\n                    loss impairs microglial engulfment of BLA\n                    <jats:sup>\u2192vHPC<\/jats:sup>\n                    PNs synapses, leading to aberrant synaptic accumulation. Our findings establish C1ql2-mediated neuron-microglia cross talk that critically regulates circuit-specific synaptic pathophysiology in stress-related disorders.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2600854123","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:44:30Z","timestamp":1792601070000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["<i>C1ql2<\/i>\n                    gates stress vulnerability by regulating microglia-mediated synaptic pruning in the BLA-vHPC circuit"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2350-0782","authenticated-orcid":false,"given":"Chun-Yan","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/042v6xz23","id-type":"ROR","asserted-by":"publisher"}],"name":"Jiangxi Institute of Respiratory Diseases and Department of Pathology, The First Affiliated Hospital, 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