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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:p>\n                    Celiac disease (CeD) and rheumatoid arthritis (RA) share several key features. In both diseases HLA class II allotypes are the major genetic determinants, in both diseases there are antibodies to posttranslationally modified peptides (i.e., deamidated peptides in CeD and citrullinated peptides in RA) and in both diseases there are autoantibodies to enzymes that mediate these peptide modifications (i.e., transglutaminase 2 for CeD and peptidyl arginine deiminase 2 and 4 for RA). In CeD, recent insights obtained from studies of antigen-specific immune cells have established a mechanistic model that integrates these key features by a pivotal involvement of enzyme\u2013substrate complexes. 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A shared pathomechanism raises the possibility that RA, like exogenous cereal gluten proteins drive immunopathology in CeD, is driven by T cell reactions to foreign antigen.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2600933123","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:37:20Z","timestamp":1788543440000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["One mechanism, two diseases: Involvement of enzyme\u2013substrate complexes in the pathogenesis of celiac disease and rheumatoid arthritis"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-704X","authenticated-orcid":false,"given":"Ludvig M.","family":"Sollid","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"KG Jebsen Center for Specific Autoimmune Therapy and Norwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo","place":["Oslo, Norway"]},{"id":[{"id":"https:\/\/ror.org\/00j9c2840","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology, Oslo University Hospital-Rikshospitalet","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-017-0985-7"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-031521-032634"},{"issue":"1","key":"e_1_3_4_3_2","first-page":"S3","article-title":"Review article: Epidemiology of coeliac disease","volume":"56","author":"Makharia G. 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