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These defects are mechanistically linked: BIM deletion or enforced mTORC1 activity rescues the survival and proliferative failures, respectively, of CORVET\/HOPS-deficient T cells. Our work establishes CORVET\/HOPS as fundamental couplers linking nutrient acquisition to immune signaling, revealing a targetable node for immuno-metabolic therapy.<\/jats:p>","DOI":"10.1073\/pnas.2601318123","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:41Z","timestamp":1787762021000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Amino acid homeostasis by CORVET\/HOPS: A metabolic and stress resilience checkpoint for T cells"],"prefix":"10.1073","volume":"123","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01whmzn59","id-type":"ROR","asserted-by":"publisher"}],"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central 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