{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:16:05Z","timestamp":1785406565989,"version":"3.56.0"},"reference-count":70,"publisher":"National Academy of Sciences","issue":"28","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI171045"],"award-info":[{"award-number":["R01 AI171045"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI133623"],"award-info":[{"award-number":["R01 AI133623"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK129690"],"award-info":[{"award-number":["R01 DK129690"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association of VA Surgeons","award":["Faculty Research Award 2022"],"award-info":[{"award-number":["Faculty Research Award 2022"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,7,14]]},"abstract":"<jats:p>\n                    Indoleamine 2,3-dioxygenase (IDO), the enzyme responsible for tryptophan catabolism, is protective in many autoimmune and inflammatory diseases. We previously developed a localized immunomodulation approach through the fusion of IDO to a carbohydrate binding protein [E. Bracho-Sanchez\n                    <jats:italic toggle=\"yes\">et al.<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Nat. Biomed. Eng.<\/jats:italic>\n                    <jats:bold>7<\/jats:bold>\n                    , 1156\u20131169 (2023)]. Here we further develop IDO as a protein therapeutic for inflammation, investigating systemic delivery via conjugation of poly(ethylene glycol) (PEG) to IDO. PEGylation extended circulation time and treatment PEG-IDO demonstrated therapeutic efficacy in five autoimmune and inflammatory models. Treatment with a single dose of PEG-IDO resulted in reversal of hind limb paralysis in experimental autoimmune encephalomyelitis as model of multiple sclerosis; protected against hepatic damage in liver ischemia-reperfusion injury; prevention of abdominal aortic aneurysm; and decreased severity of imiquimod-induced psoriasis. Treatment with two doses of PEG-IDO provided maintenance of body weight and colon length in acute ulcerative colitis. PEG-IDO treatment increased regulatory T cell populations and reduced pathogenic Th17 cell populations and inflammatory cytokine production. Systemic delivery of PEG-IDO had little-to-no off-target effects. Mice maintained immunocompetency, clearing the\n                    <jats:italic toggle=\"yes\">Listeria<\/jats:italic>\n                    monocytogenes infection, and had no observed toxicity. Additionally, PEG-IDO increased serum kynurenine, consistent with a kynurenine-mediated mechanism of action. These findings demonstrate systemic immunomodulation via circulating PEG-IDO ameliorates a breadth of disparate autoinflammatory diseases, protecting against inflammation-driven tissue destruction in spinal cord, liver, abdominal aorta, skin, and colon, while presenting a positive safety profile, and expanding the scope of potential applications for this therapeutic approach.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2602536123","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:38:23Z","timestamp":1783532303000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Circulating PEG-indoleamine 2,3-dioxygenase ameliorates diverse inflammatory diseases without toxicity or compromising immunocompetence"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-8872","authenticated-orcid":false,"given":"Jennifer A.","family":"Simonovich","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Clark","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-3555","authenticated-orcid":false,"given":"Alexander J.","family":"Kwiatkowski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9673-2887","authenticated-orcid":false,"given":"Madeline J.","family":"Fuchs","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1821-458X","authenticated-orcid":false,"given":"Mariana E.","family":"Viso","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina L.","family":"Macias","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Pinto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1576-8584","authenticated-orcid":false,"given":"Abhishek P.","family":"Shrestha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4093-7004","authenticated-orcid":false,"given":"Tran B.","family":"Ngo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]},{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Duarte","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongyao","family":"Hu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyi","family":"Lu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Hartman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Su","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore T.","family":"Scali","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]},{"name":"Malcom Randall Department of Veterans Affairs Medical Center","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2257-0111","authenticated-orcid":false,"given":"Scott A.","family":"Berceli","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]},{"name":"Malcom Randall Department of Veterans Affairs Medical Center","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-6039","authenticated-orcid":false,"given":"Ashish K.","family":"Sharma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Gilbert R.","family":"Upchurch","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-0492","authenticated-orcid":false,"given":"Shamima","family":"Islam","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xf75524","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute","place":["Tampa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Wanchoo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2259-0809","authenticated-orcid":false,"given":"Gregory A.","family":"Hudalla","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Robinson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida","place":["Gainesville"]},{"name":"Malcom Randall Department of Veterans Affairs Medical Center","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zarrinpar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, College of Medicine, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Avram","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xf75524","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute","place":["Tampa"]},{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Oncological Sciences, Morsani College of Medicine, University of South Florida","place":["Tampa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6474-7769","authenticated-orcid":false,"given":"Benjamin G.","family":"Keselowsky","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140392"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.013"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3502"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642195"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903670"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.6752"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5396"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900986"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020052"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5380.1191"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2020.100116"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061564"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718757482"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14779"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2912411"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103734"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25301"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101717"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regen.2019.100015"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-023-01025-1"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07129-6"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.170"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2015.11.015"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2011.06.012"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10600"},{"key":"e_1_3_4_26_2","unstructured":"Biopharma PEG FDA approved PEGylated drugs by 2025. https:\/\/www.biochempeg.com\/article\/58.html. Accessed 24 April 2025."},{"key":"e_1_3_4_27_2","unstructured":"K. Dey PEGylated drugs market size share and industry analysis 2032. MRFR (2019). https:\/\/www.marketresearchfuture.com\/reports\/pegylated-drugs-market-8436. Accessed 23 April 2025."},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.03.002"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00619"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.10.009"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00639"},{"key":"e_1_3_4_32_2","first-page":"1329","article-title":"The role of myeloid-derived suppressor cells in multiple sclerosis and its animal model","volume":"15","author":"Jiang Q.","year":"2024","unstructured":"Q. Jiang, J. Duan, L. Van Kaer, G. Yang, The role of myeloid-derived suppressor cells in multiple sclerosis and its animal model. Aging Dis. 15, 1329\u20131343 (2024).","journal-title":"Aging Dis."},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.989933"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092053"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.788940"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03096"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad312"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2024.104938"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3974"},{"key":"e_1_3_4_40_2","volume-title":"StatPearls","author":"Gerriets V.","year":"2025","unstructured":"V. Gerriets, A. Goyal, \u201cTumor necrosis factor inhibitors\u201d in StatPearls, K. Khaddour, Ed. (StatPearls Publishing, 2025)."},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv179"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1292-x"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0229-7"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6849138"},{"key":"e_1_3_4_45_2","unstructured":"European Medicines Agency (EMA) Mircera. https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/mircera. Accessed 28 April 2025."},{"key":"e_1_3_4_46_2","first-page":"422","article-title":"Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout","volume":"9","author":"Biggers K.","year":"2008","unstructured":"K. Biggers, N. Scheinfeld, Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout. Curr. Opin. Investig. Drugs 9, 422\u2013429 (2008).","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_3_4_47_2","first-page":"649","article-title":"Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol","volume":"46","author":"Davis S.","year":"1981","unstructured":"S. Davis, A. Abuchowski, Y. K. Park, F. F. Davis, Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol. Clin. Exp. Immunol. 46, 649\u2013652 (1981).","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2015.1113254"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1873-1"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00760"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394309-5.00006-7"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11020400"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88489-w"},{"key":"e_1_3_4_54_2","first-page":"675","article-title":"The role of immune mechanisms in abdominal aortic aneurysm: Could it be a promising therapeutic strategy?","volume":"39","author":"Dinc R.","year":"2023","unstructured":"R. Dinc, The role of immune mechanisms in abdominal aortic aneurysm: Could it be a promising therapeutic strategy? Acta Cardiol. Sin. 39, 675\u2013686 (2023).","journal-title":"Acta Cardiol. Sin."},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02376"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44385-025-00040-y"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001628"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00176-5"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130715"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900291"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.08.031"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095720"},{"key":"e_1_3_4_63_2","unstructured":"eLabProtocols ZYM-5052 medium for auto-induction. https:\/\/www.elabprotocols.com\/protocols\/#!protocol=38033. Accessed 7 March 2024."},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.04.073"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250004"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367781780958577"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6522"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312438738"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2602536123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:38:49Z","timestamp":1783532329000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2602536123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":70,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2026,7,14]]}},"alternative-id":["10.1073\/pnas.2602536123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2602536123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2602536123"}}