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This drinking behavior subsequently activates GABAergic neurons in the MnPO (MnPO\n                    <jats:sup>GABA<\/jats:sup>\n                    ), which then inhibit GABAergic neurons in the ventral tegmental area (VTA\n                    <jats:sup>GABA<\/jats:sup>\n                    ), leading to disinhibition of reward-encoding dopaminergic VTA neurons (VTA\n                    <jats:sup>DA<\/jats:sup>\n                    ), ultimately mediating the extinction of stress-induced anxiety-like behaviors. The present study defines cortical\u2013hypothalamic\u2013midbrain connections underlying the anxiety-relieving effects of drinking behavior, providing a circuit basis for innate stress coping strategies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2602749123","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:59:54Z","timestamp":1784221194000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Neural circuits for stress-induced water drinking in relief of anxiety"],"prefix":"10.1073","volume":"123","author":[{"given":"Lan","family":"Tang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04c4dkn09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Center for Advance Interdisciplinary Science and Biomedicine of Institute of Health and Medicine, 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