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Without VAMP7, TBC1D15-17 remains bound to Rab7 but fails to activate its hydrolysis, resulting in elevated GTP-bound Rab7 and impaired MLCs untethering. Consistently, expression of GTP-locked Rab7\n                    <jats:sup>Q67L<\/jats:sup>\n                    or GTPase-activating protein-dead TBC1D15-17\n                    <jats:sup>\u0394GAP<\/jats:sup>\n                    phenocopies the mitochondrial defects, while GDP-bound Rab7\n                    <jats:sup>T22N<\/jats:sup>\n                    or wild-type TBC1D15-17 restores the MLC dynamics. Considering that SNARE proteins mediate membrane fusion, our results demonstrate a role for VAMP7 in glial mitochondrial dynamics via organelle contacts, impacting neuron survival in a non-cell-autonomous manner.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2603069123","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:38:12Z","timestamp":1784914692000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["VAMP7-dependent mitochondria\u2013lysosome contacts contribute to glial mitochondrial dynamics and dopaminergic neuron survival"],"prefix":"10.1073","volume":"123","author":[{"given":"Honglei","family":"Wang","sequence":"first","affiliation":[{"name":"The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University","place":["Nanjing, 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