{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:29:31Z","timestamp":1792646971593,"version":"4.5.0"},"reference-count":82,"publisher":"National Academy of Sciences","issue":"34","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32430038 82271244 32221003"],"award-info":[{"award-number":["32430038 82271244 32221003"]}]},{"name":"National Science and Technology Major Program","award":["2021ZD0204404"],"award-info":[{"award-number":["2021ZD0204404"]}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2022266"],"award-info":[{"award-number":["2022266"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New Cornerstone Science Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:p>\n                    Spinal projection neurons (SPNs) relay somatosensory information to the brain, yet how molecularly defined SPN subsets transmit noxious mechanical signals to drive nocifensive behaviors remains unclear. Here, we identify\n                    <jats:italic toggle=\"yes\">Sncg<\/jats:italic>\n                    -expressing SPNs (\n                    <jats:italic toggle=\"yes\">\n                      Sncg\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    SPNs) that convey noxious mechanical signals through a spinoreticular ascending pathway. Using intersectional genetics, anatomical tracing, and pathway-specific manipulations in mice, we show that\n                    <jats:italic toggle=\"yes\">\n                      Sncg\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    SPNs project predominantly to the parabrachial nucleus and the lateral reticular nucleus (LRN). Functional analyses reveal that\n                    <jats:italic toggle=\"yes\">\n                      Sncg\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    spinoreticular pathway transmits noxious mechanical information. LRN neurons receiving\n                    <jats:italic toggle=\"yes\">Sncg<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    spinal input are required for nocifensive behaviors elicited by noxious mechanical stimulation and contribute to mechanical allodynia of neuropathic pain. Monosynaptic tracing identifies local interneurons innervating\n                    <jats:italic toggle=\"yes\">Sncg<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    SPNs, providing a substrate for spinal gating of ascending mechanical signals. These findings highlight a spinoreticular circuit involving the LRN that is essential for nocifensive behaviors to noxious mechanical stimuli.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2604642123","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:37:08Z","timestamp":1787161028000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["A spinoreticular pathway mediates nocifensive responses to noxious mechanical stimuli"],"prefix":"10.1073","volume":"123","author":[{"given":"Yuan","family":"Liu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034t30j35","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences","place":["Shanghai, China"]},{"id":[{"id":"https:\/\/ror.org\/030bhh786","id-type":"ROR","asserted-by":"publisher"}],"name":"Department 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