{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:04:02Z","timestamp":1789581842422,"version":"build-2803163510"},"reference-count":124,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["1R01AG071512"],"award-info":[{"award-number":["1R01AG071512"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["1R01AG071512"],"award-info":[{"award-number":["1R01AG071512"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["1R21AG073684"],"award-info":[{"award-number":["1R21AG073684"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS101967"],"award-info":[{"award-number":["NS101967"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS133688"],"award-info":[{"award-number":["NS133688"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["AG077396"],"award-info":[{"award-number":["AG077396"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of War","doi-asserted-by":"publisher","award":["HT94252310443"],"award-info":[{"award-number":["HT94252310443"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["P01CA236778"],"award-info":[{"award-number":["P01CA236778"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["RO1AGs066707"],"award-info":[{"award-number":["RO1AGs066707"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG073323"],"award-info":[{"award-number":["U01 AG073323"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX005976"],"award-info":[{"award-number":["I01BX005976"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:p>Dysregulated dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol-O-methyltransferase (COMT), an enzyme critical for degrading DA in the dorsolateral prefrontal cortex, have been implicated in behavioral and neuropsychiatric alterations associated with schizophrenia (SCZ). Adverse neuropsychiatric effects have also been reported in Parkinson\u2019s disease (PD) patients administered COMT inhibitors in combination with other DA-enhancing therapies. COMT exists as two isoforms: a soluble short isoform (S-COMT) and a membrane-bound long isoform (MB-COMT). These variants differ in their N-terminal domains, with MB-COMT being the predominant brain isoform. Here, unbiased proteomic and biochemical analyses show that genetic loss of MB-COMT disrupts DA signaling and perturbs pathways governing synaptic and mitochondrial function, iron and copper homeostasis, and redox balance. Limited proteolysis mass spectrometry (LiP-MS) further revealed that MB-COMT deficiency triggers widespread protein structural alterations, a molecular event commonly occurring in neurodegenerative conditions but not as well studied in neuropsychiatric diseases. Our results show that MB-COMT is a molecular hub that connects multiple cellular pathways whose differential dysregulation underlies the pathophysiology of complex neuropsychiatric diseases such as SCZ. Thus, MB-COMT is identified as a key regulator of brain DA biology, loss of which activates cellular stress response pathways, revealing potential targets for therapeutic intervention.<\/jats:p>","DOI":"10.1073\/pnas.2606205123","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:37:27Z","timestamp":1789580247000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Catechol-\n                    <i>O<\/i>\n                    -methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-2437","authenticated-orcid":false,"given":"Sunil Jamuna","family":"Tripathi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9456-4322","authenticated-orcid":false,"given":"Suwarna","family":"Chakraborty","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil B.","family":"Wood","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biophysics, Johns Hopkins University","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillon","family":"Hoopes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-6966","authenticated-orcid":false,"given":"Sarah","family":"Barker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychiatry, Case Western Reserve University","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/01gc0wp38","id-type":"ROR","asserted-by":"publisher"}],"name":"Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Case Western Reserve University, School of Medicine","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurosciences, Case Western Reserve University, School of Medicine","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4508-5217","authenticated-orcid":false,"given":"Edwin","family":"V\u00e1zquez-Rosa","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychiatry, Case Western Reserve University","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/01gc0wp38","id-type":"ROR","asserted-by":"publisher"}],"name":"Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Case Western Reserve University, School of Medicine","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurosciences, Case Western Reserve University, School of Medicine","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu","family":"An","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, Johns Hopkins University","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxuan","family":"Ma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xjacd83","id-type":"ROR","asserted-by":"publisher"}],"name":"Genomic Medicine Institute Lerner Research Institute Cleveland Clinic","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xjacd83","id-type":"ROR","asserted-by":"publisher"}],"name":"Genomic Medicine Institute Lerner Research Institute Cleveland Clinic","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshana M.","family":"Sharma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/012jban78","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina","place":["Charleston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-2847","authenticated-orcid":false,"given":"Feixiong","family":"Cheng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xjacd83","id-type":"ROR","asserted-by":"publisher"}],"name":"Genomic Medicine Institute Lerner Research Institute Cleveland Clinic","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Medicine Cleveland Clinic Lerner College of Medicine, Case Western Reserve University","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Case Comprehensive Cancer Center, Case Western Reserve University, School of Medicine","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-9726","authenticated-orcid":false,"given":"Bobby","family":"Thomas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/012jban78","id-type":"ROR","asserted-by":"publisher"}],"name":"Darby Children\u2019s Research Institute, Medical University of South Carolina","place":["Charleston"]},{"id":[{"id":"https:\/\/ror.org\/012jban78","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Medical University of South Carolina","place":["Charleston"]},{"id":[{"id":"https:\/\/ror.org\/012jban78","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, Medical University of South Carolina","place":["Charleston"]},{"id":[{"id":"https:\/\/ror.org\/012jban78","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Drug Discovery, Medical University of South Carolina","place":["Charleston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-3750","authenticated-orcid":false,"given":"Benjamin C.","family":"Orsburn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-2193","authenticated-orcid":false,"given":"Stephen D.","family":"Fried","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biophysics, Johns Hopkins University","place":["Baltimore"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemistry, Johns Hopkins University","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-7022","authenticated-orcid":false,"given":"Solomon H.","family":"Snyder","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine","place":["Baltimore"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-6577","authenticated-orcid":false,"given":"Andrew A.","family":"Pieper","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychiatry, Case Western Reserve University","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/01gc0wp38","id-type":"ROR","asserted-by":"publisher"}],"name":"Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Case Western Reserve University, School of Medicine","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurosciences, Case Western Reserve University, School of Medicine","place":["Cleveland"]},{"id":[{"id":"https:\/\/ror.org\/01nh3sx96","id-type":"ROR","asserted-by":"publisher"}],"name":"Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center","place":["Cleveland"]},{"name":"Cleveland Alzheimer\u2019s Disease Research Center","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6103","authenticated-orcid":false,"given":"Bindu D.","family":"Paul","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine","place":["Baltimore"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.126.3270.400"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111134598"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1792-04.2005"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666150612225836"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.3997.598"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64731-3"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001767"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1993.12.253"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb19083.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2960595"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00556-0"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00345"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.262790"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00013a008"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0665-07.2007"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb38132.x"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1996.0129"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63030972.x"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60846-7"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.9991"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06889.x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01121-6"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01730-X"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070532"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000459"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780120085010"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/14.2.179"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800230088014"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00031-4"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.11.1078"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20037"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199606000-00007"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.758679"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(24)01423-6"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.120178"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1342-1"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1124-04.2004"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2021.11.002"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00677"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00724"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21126"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13111513"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01182-7"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90750-B"},{"key":"e_1_3_4_47_2","first-page":"171","article-title":"Catechol-O-methyltransferase and Parkinson\u2019s disease","volume":"40","author":"Reches A.","year":"1984","unstructured":"A. Reches, S. Fahn, Catechol-O-methyltransferase and Parkinson\u2019s disease. Adv. Neurol. 40, 171\u2013179 (1984).","journal-title":"Adv. Neurol."},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01285556"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2023.8"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13970"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00547-4"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)02204-X"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14050514"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(25)13536-0"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(25)13535-9"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(86)90242-X"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1314"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.173909"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970215)47:4<449::AID-JNR10>3.0.CO;2-U"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2012.657260"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.4.C1143"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2424"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2007.01805.x"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/bios12070500"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-003-0011-2"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.08.013"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.03.036"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines14020463"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040492"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18324-9"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13902"},{"key":"e_1_3_4_72_2","article-title":"2026) Hepatocyte specific Rab27a knockout aggravates metabolic dysfunction associated fatty liver disease","volume":"5","author":"Hu J. Y.","year":"1872","unstructured":"J. Y. Hu , 2026) Hepatocyte specific Rab27a knockout aggravates metabolic dysfunction associated fatty liver disease. Biochim. Biophys. Acta Mol. Basis Dis. 5, 168223 (1872).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158452"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.160"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2528478122"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13136"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017225118"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2024.102511"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2025.e00757"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2025.e00719"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-026-02142-z"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.100"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2999"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.3c00887"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c03270"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600041"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crneur.2024.100136"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4354"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-020-01080-6"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1080\/152165401317291156"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.43"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00718"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.11.015"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231912056"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1080\/13554790903456209"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021303"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314124200"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi972274d"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101856"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2025.07.004"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.06.060"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1092"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2016.43"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7321"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1153439"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.138"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01135-3"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007020170087"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90652-5"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00454"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00125.x"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19981201)54:5<691::AID-JNR14>3.0.CO;2-F"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.06.030"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64020825.x"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1483913"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0656-x"},{"key":"e_1_3_4_118_2","doi-asserted-by":"crossref","unstructured":"K. Zuhra Regulation of mammalian cellular metabolism by endogenous cyanide production. Nat. Metab. 7 531\u2013555 (2025).","DOI":"10.1038\/s42255-025-01225-w"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103595"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01972-8"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.7.1103"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010060"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.012748"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1011"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2606205123","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2606205123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:38:22Z","timestamp":1789580302000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2606205123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":124,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,9,22]]}},"alternative-id":["10.1073\/pnas.2606205123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2606205123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2606205123"}}