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This study combined electroencephalography and psychopharmacology to examine the effects of a catecholaminergic stimulant (methylphenidate) on processing sentences containing local syntactic ambiguities. Methylphenidate amplified the P600 event-related potential effect, which has been linked to the recruitment of cognitive resources for processing sentences with increased syntactic load. The drug\u2019s impact on semantic processing was subtler, showing a suggestive attenuation of the N400 effect to ambiguous sentences. Furthermore, the increase in the P600 effect under methylphenidate was most pronounced in participants with lower working memory capacity. This study provides evidence for linking catecholamine activity to syntactic unification in healthy individuals. 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