{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:55:59Z","timestamp":1790625359445,"version":"4.1.0"},"reference-count":96,"publisher":"National Academy of Sciences","issue":"40","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:p>\n                    Conversion of mechanical stimuli into electrical signals underlies many physiological processes, including auditory and vestibular functions. In vertebrate hair cells, the mechanoelectrical transduction complex (METC)\u2014a multiprotein and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent sound and motion receptor\u2014is located at the stereociliary tips within the hair bundle. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) proteins function as the mechanosensitive channels in this complex. To investigate the evolutionary origins of vertebrate hair cells we have evaluated whether cnidarian nematocytes are related to the vertebrate hair cells at the cellular and molecular levels. The hair-bundles of nematocytes resemble those found in vertebrate hair cells, including the presence of extracellular protein tethers. Cnidarian TMC5 and TMC7 localize to the hair bundles, the proposed site of MET channel activity. MET channel permeant FM dye uptake experiments demonstrate that mechanically activated nematocytes incorporate dye through their stereovillar bundle and not through the kinocilium-like cnidocil. RNAi-mediated knockdown of\n                    <jats:italic toggle=\"yes\">TMC5<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">TMC7<\/jats:italic>\n                    significantly reduced nematocyte eversion in\n                    <jats:italic toggle=\"yes\">Clytia<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Nematostella<\/jats:italic>\n                    , pointing to their fundamental role in mechanotransduction. In contrast, similar experiments show that the TRP channel NompC is not required in this response. Overall, we present morphological, behavioral, pharmacological, bioinformatic, and reverse genetics data supporting an evolutionary relationship between the common ancestors of cnidarian nematocytes and vertebrate hair cells. Our findings highlight the conservation of mechanotransduction mechanisms based on TMC channels and offer evolutionary insights to the origin of mechanical signaling based on stereovillar bundle deflection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2607106123","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:02:56Z","timestamp":1790622176000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Cnidarian mechanosensory cells as ancestors of vertebrate hair cells: Molecular targeting of an ancient mechanotransduction complex"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-3475","authenticated-orcid":false,"given":"Zeeshan Z.","family":"Banday","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024mw5h28","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Molecular Biology, The 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