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U.S.A."],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:p>\n                    Heritable microbes profoundly influence insect biology, yet the traits they confer often evolve rapidly and differ among closely related symbiont strains. Despite their importance, we lack a clear understanding of how novel traits arise in symbionts and how this diversity influences host ecology in nature. The aphid facultative symbiont\n                    <jats:italic toggle=\"yes\">Regiella insecticola<\/jats:italic>\n                    is ideally suited to address this question due to strong lineage-specific variation in host benefits. By generating 20 high-quality genomes, we found that\n                    <jats:italic toggle=\"yes\">Regiella<\/jats:italic>\n                    \u2019s evolution is driven largely by gene gains mediated by mobile genetic elements (MGEs). A plasmid (pRILSR1) encoding a type IV secretion system and a highly expressed predicted effector has spread horizontally between distantly related\n                    <jats:italic toggle=\"yes\">Regiella<\/jats:italic>\n                    clades associated with pea aphids. Notably, only pRILSR1-bearing strains confer protection against the fungal pathogen\n                    <jats:italic toggle=\"yes\">Pandora neoaphidis<\/jats:italic>\n                    . Moreover, loss of the plasmid by a protective strain in culture resulted in the loss of protection, indicating that pRILSR1 is required for the defensive phenotype. In a multiyear field study, pRILSR1 frequency varied systematically among host plant-associated pea aphid populations and predicted differences in symbiont-mediated fungal resistance. Together, our results show that gain and loss of a single MGE contributes to divergence in a key adaptive trait, providing a mechanism by which symbiont evolution generates phenotypic differences among host populations.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2607226123","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:12:05Z","timestamp":1790017925000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1654-7740","authenticated-orcid":false,"given":"Balig","family":"Panossian","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/026zzn846","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological and Behavioural Sciences, Queen Mary University of London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5025-8497","authenticated-orcid":false,"given":"Matthew R.","family":"Kolp","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/020f3ap87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, University of Tennessee","place":["Knoxville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoping","family":"Wu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/026zzn846","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological and Behavioural Sciences, Queen Mary University of London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keertana","family":"Tallapragada","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0130frc33","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, University of North Carolina at Chapel Hill","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-1480","authenticated-orcid":false,"given":"Vilas","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Entomology, University of Georgia","place":["Athens"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott B.","family":"Goldstein","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/020f3ap87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, University of Tennessee","place":["Knoxville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry M.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Entomology, University of Georgia","place":["Athens"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee M.","family":"Henry","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/026zzn846","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological and Behavioural Sciences, Queen Mary University of London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-4732","authenticated-orcid":false,"given":"Benjamin J.","family":"Parker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/020f3ap87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, University of Tennessee","place":["Knoxville"]},{"id":[{"id":"https:\/\/ror.org\/0130frc33","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, University of North Carolina at Chapel Hill","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_3_4_1_2","volume-title":"Endosymbiosis of Animals with Plant Microorganisms","author":"Buchner P.","year":"1965","unstructured":"P. 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