{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:56:30Z","timestamp":1781110590058,"version":"3.54.1"},"reference-count":61,"publisher":"National Academy of Sciences","issue":"20","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1304400"],"award-info":[{"award-number":["2022YFA1304400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technologies R&D Program of Guangdong Province","award":["2026B0202180004"],"award-info":[{"award-number":["2026B0202180004"]}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32222071"],"award-info":[{"award-number":["32222071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Science and Technology Program","award":["2023B03J1313"],"award-info":[{"award-number":["2023B03J1313"]}]},{"DOI":"10.13039\/501100009997","name":"MOA | Earmarked Fund for Modern Agro-industry Technology Research System","doi-asserted-by":"publisher","award":["nycytx-001"],"award-info":[{"award-number":["nycytx-001"]}],"id":[{"id":"10.13039\/501100009997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:p>\n                    The white-backed planthopper (\n                    <jats:italic toggle=\"yes\">Sogatella furcifera<\/jats:italic>\n                    ) serves as the vector for the southern rice black-streaked dwarf virus (SRBSDV), with varying transmission efficiencies across populations. This research identifies\n                    <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                    , a common insect symbiont, as a key facilitator in breaching the salivary gland barrier for SRBSDV, revealing a mechanism by which the virus exploits an insect symbiont for transmission. Through field and laboratory investigations, it was observed that high-transmission (HT) planthopper populations contained high levels of\n                    <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                    , while low-transmission (LT) populations had minimal titers. Experiments involving thoracic injections confirmed\n                    <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                    \u2019s specific role in infiltrating salivary glands, as SRBSDV was unable to colonize glands in\n                    <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                    -depleted insects despite being present systemically. Ultrastructural analysis showed\n                    <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                    enveloping SRBSDV particles within gland cells, further supported by molecular assays indicating a direct interaction between\n                    <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                    surface protein (WSP) and viral P8 capsid protein. Disruption of this interaction using anti-WSP antibodies reduced salivary gland viral load and transmission rates, underscoring its functional importance. These results contrast with\n                    <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                    \u2019s antiviral effects in mosquitoes, highlighting a context-dependent \u201chitchhiking\u201d strategy for viral dissemination. The WSP\u2013P8 interaction presents a specific target for inhibiting SRBSDV transmission without resorting to pesticides, proposing a symbiont-informed approach as a sustainable strategy against rice viral diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2607638123","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:39:43Z","timestamp":1778693983000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["<i>Wolbachia<\/i>\n                    -mediated viral transmission enhancement in insect vectors"],"prefix":"10.1073","volume":"123","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University","place":["Guangzhou, China"]},{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-9390","authenticated-orcid":false,"given":"Shunkang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University","place":["Guangzhou, China"]},{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University","place":["Guangzhou, China"]},{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupei","family":"Ai","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilei","family":"Huang","sequence":"additional","affiliation":[{"name":"Instrumental Analysis and Research Center, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-6324","authenticated-orcid":false,"given":"Xin","family":"Yi","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-414X","authenticated-orcid":false,"given":"Guohui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9499-4170","authenticated-orcid":false,"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-9510","authenticated-orcid":false,"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University","place":["Guangzhou, China"]},{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural 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