{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:40:32Z","timestamp":1792690832591,"version":"4.5.0"},"reference-count":78,"publisher":"National Academy of Sciences","issue":"43","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,27]]},"abstract":"<jats:p>Huntingtin-associated protein 40 (HAP40) forms a stable protein complex with huntingtin (HTT). Its cellular function and how HAP40 loss influences mutant HTT (mHTT) abundance and pathobiology are currently unclear. Here, using diverse cellular models and omics methods, we demonstrate that HAP40 is an obligate interaction partner of HTT and through its binding controls HTT interactions and the abundance of HTT-associated proteins, indicating that it functions as a HTT interaction regulatory unit. Also, loss of HAP40 in mHTT-expressing striatal cells impairs autophagic protein degradation and triggers transcriptional activation of the CLEAR network, demonstrating that it functions as a proteostasis regulator that acts on quality control pathways. Finally, mHTT-expressing cells lacking HAP40 showed increased secretion of a ~205 kDa mHTT fragment through an endoplasmic reticulum (ER)\/Golgi-associated route, indicating that striatal cells reduce intracellular mHTT-induced proteotoxicity through activation of secretory pathways. Together, these results establish HAP40 as a critical proteostasis regulator that through controlling HTT interactions maintains cellular homeostasis.<\/jats:p>","DOI":"10.1073\/pnas.2611301123","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:59:46Z","timestamp":1792688386000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-9107","authenticated-orcid":false,"given":"Eduardo","family":"Silva Ramos","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Boeddrich","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haenig","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Trepte","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orchid","family":"Ammar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-536X","authenticated-orcid":false,"given":"Christopher","family":"Secker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]},{"id":[{"id":"https:\/\/ror.org\/02eva5865","id-type":"ROR","asserted-by":"publisher"}],"name":"Distributed Algorithms and Supercomputing, Zuse Institute Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-4666","authenticated-orcid":false,"given":"Oliver","family":"Popp","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Proteomics Platform, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andranik","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Core Unit Bioinformatics, Berlin Institute of Health at Charit\u00e9, University Medicine Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Beetz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Roth","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6653-5545","authenticated-orcid":false,"given":"Roxane M.","family":"Papawassiliou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5020-9818","authenticated-orcid":false,"given":"Luisanna C.","family":"Hernandez Jeppesen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4972-8804","authenticated-orcid":false,"given":"Theo","family":"Wallenfang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3395-157X","authenticated-orcid":false,"given":"Brandon","family":"Keith","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"Structural Genomics Consortium, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-391X","authenticated-orcid":false,"given":"Rachel J.","family":"Harding","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"Structural Genomics Consortium, University of Toronto","place":["Toronto, Canada"]},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology and Toxicology, University of Toronto","place":["Toronto, Canada"]},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"Leslie Dan Faculty of Pharmacy, University of Toronto","place":["Toronto, Canada"]},{"id":[{"id":"https:\/\/ror.org\/042xt5161","id-type":"ROR","asserted-by":"publisher"}],"name":"Princess Margaret Cancer Centre, University Health Network","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-8284","authenticated-orcid":false,"given":"Franziska","family":"Schindler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2895-6051","authenticated-orcid":false,"given":"Tomas","family":"Koudelka","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Allosteric Proteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Scharek","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Zenkner","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Neuendorf","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Golusik","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mertins","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Proteomics Platform, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Piazza","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Allosteric Proteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4660-287X","authenticated-orcid":false,"given":"Sigrid","family":"Schnoegl","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-1630","authenticated-orcid":false,"given":"Erich E.","family":"Wanker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04p5ggc03","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroproteomics, Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13413"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.09.036"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01185-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51216-w"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01850-w"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105574"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-155"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524575113"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-115"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.185710"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14853"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2022.100275"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-95672-7.00016-9"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25502"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010302"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2023.06.002"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02895-4"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105476"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3101"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1420103111"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl440"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2789"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610628104"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.06.007"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200509091"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2799"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae410"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.008"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.236"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049838"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.5.1393"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00939-5"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20178071"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2020.06.008"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104748"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr306"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174447"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204592"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033993"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00542-2"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00538-3"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00669-y"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.5.8823"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.05.011"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702824200"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.001"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)47429-2"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.028"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1722-1"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.9.1107"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06562.x"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.10.028"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202110151"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104616"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.04.016"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90685-5"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.021"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00075"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2020.01.003"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.024"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.359307"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01414-x"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21637-y"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado5264"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1865-20.2020"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0118-17.2017"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-07-0599"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8227-7"},{"key":"e_1_3_4_72_2","first-page":"1335","article-title":"Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane","volume":"7","author":"Brandstaetter H.","year":"2014","unstructured":"H. Brandstaetter, A. J. Kruppa, F. Buss, Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane. Dis. Model Mech. 7, 1335\u20131340 (2014).","journal-title":"Dis. Model Mech."},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102219"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00121-1"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516217112"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3761"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3457"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071714-033828"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2611301123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:59:47Z","timestamp":1792688387000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2611301123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":78,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2026,10,27]]}},"alternative-id":["10.1073\/pnas.2611301123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2611301123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"2026-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2611301123"}}