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Rescue of impaired TSDR demethylation under mTORC1 inhibition by the TET2 catalytic domain, together with dose-dependent impairment following heterozygous deficiency of TET2 and\/or TET3, supports a causal link between TET protein abundance and TSDR demethylation. In vivo, mTORC1 inactivation increases the frequency of cells harboring a methylated TSDR among peripheral Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    T cells, but not among developing Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    thymocytes, supporting in vivo relevance of mTORC1-dependent epigenetic remodeling. Thus, TCR\u2013mTORC1 signaling promotes epigenetic stabilization of Foxp3 expression through translational control of TET proteins, revealing an unrecognized role for mTORC1 in iTreg cell differentiation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2612904123","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:18:26Z","timestamp":1790698706000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["TCR\u2013mTORC1 signaling promotes epigenetic stabilization of Foxp3 expression in regulatory T cells via TET protein translation"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7986-3914","authenticated-orcid":false,"given":"Tomohide","family":"Kinoshita","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/057zh3y96","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Immunology and Microbiology, Graduate School of 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