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These two regions show a distinctive mutational signature with almost exclusively T\/A\u2192C\/G transitions, a pattern also found in other non-eukaryote-derived sequences in\n                    <jats:italic toggle=\"yes\">B. natans<\/jats:italic>\n                    , contrary to the usual GC to AT mutation bias. Notably, hypermutation occurs only on TpA dinucleotides, and only in a subset of experimental lines, suggesting a regulated process rather than random genomic instability. We propose that\n                    <jats:italic toggle=\"yes\">B. natans<\/jats:italic>\n                    targets invading DNA through localized hypermutation, reminiscent of deamination-based antiviral defense systems in animals. This prompts the idea of genome editing as a recurring immune strategy in eukaryotes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2612999123","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:53:14Z","timestamp":1785261194000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Hypermutability of integrated sequences of viral origin in a chlorarachniophyte"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8883-386X","authenticated-orcid":false,"given":"Lisa","family":"Mettrop","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02en5vm52","id-type":"ROR","asserted-by":"publisher"}],"name":"CNRS, Microbial Biodiversity and Biotechnology Laboratory (UMR 8176), Sorbonne Universit\u00e9","place":["Banyuls sur Mer, 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